When the news came out, it caused a heated discussion.
This study found that high-salt diet can regulate the activity of bone marrow-derived suppressor cells (MDSCs), thus activating the anti-tumor response of immune cells.
Many studies in the past have shown that high-salt diet will disturb the immune system of the body, stimulate immune cells to secrete more cytokines, and then cause inflammatory reactions in various tissue microenvironments.
However, in the tumor microenvironment, the situation is a little different. In order to make immune cells overcome the immunosuppression of tumors and recover their immune response and attack on tumors, the key is to enhance the pro-inflammatory activity of various cell types.
Immunosuppression of tumor is closely related to bone marrow-derived inhibitory cells. Hyperosmotic pressure caused by high-salt diet is an obvious environmental stimulus to cells, which can promote macrophage immune response mediated by transcription factor (NFAT5). Based on this, the researchers hypothesized that a high-salt diet can stimulate MDSCs to form an immunostimulatory phenotype, trigger an anti-tumor immune response, and thus inhibit tumor development.
The researchers found through mouse experiments that the osmotic pressure formed by high-salt diet can indeed inhibit the expansion of MDSCs by inhibiting the aggregation of related cytokines, so that tumor cells lose their immunosuppression, and then reactivate the anti-tumor effect of T cells.
In addition, high-salt diet can also regulate p38/MAPK-NFAT5 signaling pathway, strengthen pro-inflammatory expression, and thus enhance anti-tumor activity.
Although the above research is not fiction, its significance is limited to the research level, not the application level, because from the current research conclusion, the harm of high-salt diet far exceeds its possible anti-tumor effect.
When people eat too much salt, the body will secrete some hormones to promote the excretion of salt. Some of them, such as glucocorticoid, have the function of inhibiting the whole immune system, which will weaken the immune system's response to bacteria and lead to the decline of human resistance.
Excessive salt intake will lead to water and sodium retention and increase blood volume in blood vessels. At the same time, the increase of sodium ion concentration will lead to edema of vascular smooth muscle cells, thickening of vascular wall and narrowing of vascular lumen. In addition, the stimulation of salt on the blood vessel wall will further lead to excessive contraction of blood vessels, which will lead to increasing peripheral vascular resistance and eventually lead to an increase in blood pressure.
Because too much salt intake will increase the protein content in urine, thus increasing the burden on the kidneys, which will lead to kidney damage over time and increase the risk of kidney disease.
China has always been the hardest hit area of high-salt diet. Sichuan cuisine, Hunan cuisine and other Chinese foods are typical heavy oil and heavy salt foods.
According to the survey data, the average salt intake of Chinese residents is 1.2g/ day, but according to the recommendation of Dietary Guidelines for Residents in China, the daily salt intake of adults should not be higher than 6g, and the recommendation of WHO is more stringent and should not be higher than 5g.
Therefore, controlling salt intake is a key link that China people need to do well in their daily diet. I recommend several small methods to you, which can effectively control the salt intake.
It is suggested that the kitchen should be equipped with a salt-limiting spoon with a capacity of 2g, and the total amount of salt added to each meal for adults is one spoon, so the total amount of salt added to three meals a day is 6g/ day per person, but it should be noted that the amount of salt added to children's food should be halved.
When cooking, if you use soy sauce, bean paste, chicken essence and other salty seasonings, you should reduce the amount of salt added and don't add too much other seasonings. You can look at the ingredient list and find out the sodium content. 1g sodium is about 2.54g salt.
Using sour seasonings such as vinegar and lemon juice, or natural spices such as onion, ginger, star anise and cinnamon instead of salty seasonings can increase the flavor of food and avoid tasteless after salt control.
Sprinkle salt on the surface of the dish when cooking, and use soy sauce as dipping material instead of adding it directly to the dish, which can not only reduce the dosage, but also maintain the salty taste.
Selling vegetables, instant noodle seasoning packages and all kinds of pickled foods are the hardest hit areas with high salt. Eat these foods as little as possible, and if they are used for cooking, the amount of salt should also be controlled.
There are high potassium and low sodium salts on the market now. As long as you are not a patient with renal insufficiency, you can also use low sodium salt instead of ordinary salt.
There are actually many ways to control a high-salt diet. Of course, the most important thing is to establish your own awareness of salt restriction. In order to be healthy, it is also necessary to change habits. #39 Health Super League # # Health May Day # # Breeze Plan #
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