The increase of serum IgE is the most powerful hint of allergic diseases. Allergens enter the body to induce specific IgE, which combines with mast cells and eosinophils to make the body enter a state of specific sensitization to allergens. When the allergen comes into contact again, it will combine with the IgE receptor on the cell membrane to cause a series of biochemical reactions, and then release various bioactive mediators related to allergic reactions and inflammation, such as histamine.
Allergy is an immune disease, which is an imbalance of human immune function. In clinical investigation, patients with allergic constitution often find that multiple allergic diseases can be seen in the same patient. Compared with normal people, patients with allergic constitution have significantly higher serum IgE, more mast cells and more IgE receptors on cell membrane. Clinical medicine has proved that helper T cells and their cytokines play an important role in regulating the composition of IgE. According to the secretion of cytokines, helper cells are divided into two subgroups: TH 1 and TH2. Cytokines secreted by TH2 cells play an important role in antibody formation and allergic reaction. TH 1 and TH2 are regulated by cytokines. Under healthy conditions, TH 1 and TH2 are simultaneously balanced and regulated by helper T cells. When helper T cells lack regulatory ability or come into contact with some foreign proteins or small molecules (such as dust mites, pollen or seafood, etc.). ), TH2 is over-activated, which leads to the excessive secretion of TH2 cell hormones, leading to the increase of IgE and serum IgE concentration.
Studies have confirmed that both Lactobacillus salivarius and Lactobacillus gasseri have significant antiallergic functions, among which Lactobacillus salivarius is the most studied strain among antiallergic lactic acid bacteria, and Lactobacillus salivarius is one of the enriched probiotics. A physiologically acceptable probiotic composition with enhanced antiallergic ability is adopted. By promoting the secretion of interleukin 12(IL- 12) and interferon γ, allergic symptoms can be effectively improved, Th 1 type immune response can be regulated, immunoglobulin IgE can be inhibited, and the allergic phenomenon of Th2 type immune response can be improved. Anti-allergic probiotic strains bind to receptors on intestinal wall dendritic cells, activate the translation proteins in cells to move to the nucleus, and release a large number of cytokines, which is a link of innate immunity. Therefore, diabetic substances such as peptidoglycan, lipopolysaccharide and polysaccharide can indeed activate the development of T cells through the innate immune system.