Since the discovery of AIDS, more than 25 million people have been killed by it. In order to deal with this demon, we must first understand how this virus works. Recently, researchers from Gladstone Institute and University of California, San Francisco published two papers in Nature magazine, which analyzed the whole system elements of how HIV interacts with cells for the first time, providing important information for developing more effective treatment methods, which is also a landmark achievement in the field of AIDS research.

The study was led by Dr. Nevan J. Krogan of Gladstone Institute and others. Dr. Croghan said, "One of the keys to HIV's successful invasion of human body is that it has a set of rapid attack methods, such as using human protein to deal with ourselves." "But now we have solved the mystery of this complex process, which is a big step towards the development of new drugs and is also conducive to winning this war."

At present, there are 33 million HIV-infected people in the world, of which the United States accounts for about 4%. According to the latest data of China (up to the end of September, 20 1 1), there are 429,000 HIV-infected people and patients, among which164,000 patients and 86,000 people died. As the saying goes: know yourself and know yourself, and you will win every battle. If you want to save the victims of HIV, you need to know the function of HIV first.

In this latest study, the researchers completed the analysis of the interaction between two parts of protein. First, they constructed an overall systematic analysis, including protein in all possible protein interactions-including protein made by viruses and protein made by humans. Later, the researchers reduced these more than 500 protein interactions to one, which is the most helpful interaction for HIV infection: human protein CBF? Interaction with HIV virus protein Vif.

Usually, after HIV infection, a restriction factor called APOBEC3G can act as an inhibitor to prevent the virus from reaching its destination-CD4 T cells, which are the main functional elements of the immune system. However, the researchers found that when HIV protein Vif binds to human protein CBF? In the past, the function of Vif was enhanced, but the content of APOBEC3G was decreased, which led to the decrease of the ability of APOBEC3G to organize HIV virus, and the virus could act on CD4 T cells without obstacles.

"This is the first comprehensive analysis of the interaction between HIV and cells," said Judith H. Greenberg, another author of the article and executive director of NIH National Institute of Comprehensive Medicine. "This work is a typical example of biophysical research enhancing our understanding of diseases, and it also points out a possible therapeutic target for us."

The above is the relevant literature, what else do you ask?