Background:

Colorectal cancer is a common malignant tumor in the world and the third leading cause of cancer-related death. Although the treatment choice of CRC depends on many factors, such as the appearance, location and stage of the tumor, radiotherapy (RT) is still one of the main choices for CRC alone or in combination with surgery and/or chemotherapy.

It is mentioned in the literature that RT can reduce the tumor volume before operation, and RT can prevent recurrence during and after operation. Unfortunately, the resistance of cancer cells to radiation still limits the efficacy of RT. As we all know, there are several factors, such as gene expression disorder related to radiation sensitivity disorder, which will affect the radiation sensitivity of cells.

In recent years, high-energy carbon ion linear energy transfer (LET) radiation provides a choice for the treatment of colorectal cancer, but further improving carbon ion RT is still a research hotspot. More and more evidences show that non-coding RNA(NcRNAs), such as MicroRNA(MiRNAs) and circular RNA(circr nas), play an increasingly important role in the regulation of radiation response.

However, their biological process and potential mechanism of regulating RT tumor progression, especially the use of high-dose radiation, are still unknown.

Part of the article is illustrated:

To sum up, this study found that the expression of crcRNA CBL 1 1 in CRC cells increased significantly after carbon ion irradiation. In terms of function and mechanism, crRNA CBL. 1 1 directly regulates the expression of YWHAE through sponge-like miR-6778-5p, thus inhibiting the proliferation of colorectal cancer cells. Our results show that the Cr RNA of CBL. 11-mir6778-5p-ywhae axis plays an important regulatory role in improving the anti-colorectal cancer efficacy of carbon ion RT.