Chronic Fatigue Syndrome and Physical Exercise A global survey by the World Health Organization (WH0) shows that only 5% of people are really healthy, 20% are sick, and 75% are in sub-health state.
Sub-health, also known as the third state, also known as gray state, pre-disease state, subclinical stage, preclinical stage, incubation period and so on. It is a state between health and disease, with no clinical symptoms or mild symptoms, but with potential pathological information. Its main manifestation is chronic fatigue syndrome (CFS).
The main feature and pathological mechanism of chronic fatigue syndrome (CFS) is a group of systemic syndrome characterized by long-term extreme fatigue, with nonspecific manifestations such as fatigue, low fever (or conscious fever), sore throat, myalgia, joint pain, headache, difficulty in concentration, memory loss, sleep disorder and depression, often accompanied by headache, swollen lymph nodes and tenderness, as well as various neuropsychiatric symptoms. First, the main characteristics of chronic fatigue syndrome The incidence of CFS is high, which seriously affects patients' work activities and health.
More importantly, in the fast pace, high pressure and changeable environment of contemporary work, more and more patients complain about mental stress and chronic fatigue in clinic. For example, people who often deal with computers, middle and senior managers, middle school students before the college entrance examination, and college students during the final exam, the incidence of CFS has increased significantly.
Its main features are: 1. The inducement is complex, often caused by virus infection, important life events or psychological and social pressure; 2。
New-onset, persistent or recurrent debilitating fatigue, which lasts for more than 6 months, can not be relieved by bed rest, and no obvious abnormalities are found in various physical examinations and laboratory examinations. Symptoms are mainly chief complaints, which are difficult to define; 3。
The pathological mechanism is unknown, and there is no fundamental treatment at present. Due to the differences of people's age, adaptability, immunity and social and cultural level, the performance of CFS is also complicated.
A large number of studies have found that the occurrence of CFS is closely related to social environment, economic culture, lifestyle and genetic factors. CFS seriously affects patients' work and life, and has been paid more and more attention by the medical community.
The Centers for Disease Control and Prevention (CDC) predicts that CFS will become one of the major diseases affecting human health. Second, the etiology and pathological mechanism The pathogenesis of CFS is complex, because it often experiences a long period of stress (extreme tension and heavy mental burden) before the onset, and some patients have flu-like symptoms at the early stage of the onset.
Most people think that it may be the result of neuroendocrine and immune dysfunction caused by virus infection, stress and other factors. So far, CFS has been widely studied in medicine, but its exact reason is still unclear. Different medical experts have put forward theories such as virus infection, abnormal immune system, abnormal endocrine system, abnormal metabolism and brain disorder. Some CFS patients may have other susceptibility.
(1) Infection Because some CFS patients show flu-like symptoms, such as fever, sore throat, swollen lymph nodes, etc., fatigue, impaired cognitive function, sleep disorder, muscle joint pain and other symptoms are more common in the acute phase of many infectious diseases, and some of them can last for more than 6 months after the acute phase. Early studies believed that CFS was caused by pathogenic microorganism infection, especially EB virus (EBV) infection, and called it "post-infection fatigue syndrome".
In recent years, some people have discussed the role of viral infection in the pathogenesis of CFS from the perspective of the relationship among viral infection, cytokines and cognitive function. Studies have shown that the acute symptoms of influenza are related to the level of cytokines (such as IL-6) in blood, and there are cytokine receptors in the brain, which can affect the nervous system through these receptors.
It is found that CFS patients who have had flu-like symptoms have certain memory impairment. They think that this deficiency may be caused by cytokines released during infection, and infer that viral infection is related to cognitive impairment, that is, viral infection increases cytokines, which in turn affects the cognitive function of the body and leads to CFS. In a word, people have been studying the relationship between CFS and virus since 1980s, but so far it has not been clearly determined that virus is the cause of CFS.
It may take a long time to draw a conclusion about the relationship between virus infection and CF5. (II) Immune Factors Previous studies have shown that most CFS patients have immune system dysfunction, especially cytokines are closely related to the appearance of CFS symptoms.
So some people call CFS "chronic fatigue immune dysfunction syndrome", and different studies and individuals are different. 1。
Changes of humoral immune function There are contradictions in the reports of immunoglobulin changes in patients with CFS. It has been reported that IgA, IgG and IgM in CFS patients generally decreased, and the symptoms improved or not after immunoglobulin treatment. Others have pointed out that IgG levels in patients with CFS are elevated.
Another study found that some CFS patients have immunoglobulin subtype defects (such as IgG 1 and IgG3), which may be related to virus reactivation. However, it has also been reported that there is no difference in IgG subtypes between CFS patients and the control group.
2。 The change of cellular immune function CFS is mainly characterized by low cellular immune function.
The consistent result is that the number or activity of NK cells decreases, suggesting that the nonspecific immune function of CFS patients is low. The above results may be related to the preferential proliferation and activation of immature NK cells, the decrease of IFN-γ content of regulatory cytokines and genetic factors.
In addition, CFS also has the function of T effector cells, the function of lymphocyte proliferation, the decrease of phagocytosis of monocytes and the change of the number and proportion of T lymphocyte subsets. The decline of the above-mentioned cellular immune function can lead to the decline of the body's ability to remove and respond to foreign antigens, so that the virus lurks in the body for a long time or the foreign antigens cannot be removed.
Changes in the number and proportion of T cell subsets can also cause changes in cytokines, which in turn leads to changes in cellular immunity and humoral immunity. 3。
Changes of cytokine levels Many studies show that there are abnormalities (increase or decrease) of cytokines in patients with CFS. For example, the release of TNF-α and IL-6 in the serum of patients with CFS increased.
2. How to publish medical papers
Publishing medical papers, like other paper topics, needs to be planned and arranged according to your own needs. You have to arrange the progress of publishing medical papers according to the latest time of professional title evaluation. Secondly, you need to know the publishing level of medical papers, provincial, national or core journals. Then you have to prepare a good medical paper, which can be written in combination with your first-line work experience, and then choose the appropriate journal submission and review according to your own article category.
To publish medical papers, it is best to find a professional and authoritative paper publishing agency, such as the paper times website with many years of operating experience, whose rights and interests are guaranteed. It is also guaranteed that the publications recommended for publication are professional journals, which are included in the full-text knowledge network, Wanfang and VIP. Of course, this is not the only way. You can also contact the periodical agency to contribute, but practice has proved that unless your article is of super high quality, it often has no result, depending on your own situation.
3. Is there anything to pay attention to in medical papers?
Whether there is a good topic for publishing medical papers is the basis for writing a good medical paper. In my opinion, a good topic selection should meet the following conditions: (1) novelty: innovation is the basic starting point of scientific research, and it is also the premise of whether medical papers are accepted by journals.
Good scientific research should not only be a simple repetition of previous work, but also be innovative. The topic selection of novels does not mean profound complexity. As long as others have not thought of it, as long as others have not done it, even if it seems simple, it may be a good topic.
(2) Theoretical or practical value: A good scientific research must be valuable, both theoretically and practically. (3) Feasibility: The topic selection should be combined with the researcher's own scientific research conditions, that is, feasibility.
If possible, we should seek support from relevant funds and other projects, seek cooperation with other units, and create conditions for scientific research. 2. Whether the publishing design of medical papers is scientific and reasonable is related to the quality of topics and papers.
If there are major mistakes in project design, it is often difficult to make up for them, which will make researchers give up all their efforts and bring different degrees of losses to the country, units and individuals. Therefore, researchers should strictly control scientific research design and master the basic principles of research, such as randomness principle and comparison principle.
This requires researchers not only to have certain professional knowledge, but also to have knowledge of scientific research and design. If necessary, statisticians and other relevant experts can be invited to participate in the project setting.
3. The collection and collation of data published in medical papers should be based on the requirements of subject design, research methods and observation indicators, and standardize the collection and collation of observation data and experimental data to prevent selectivity and measurement bias. And in the process of implementation, strengthen supervision and verification, strictly control the quality, and ensure the reliability of data.
4. The correct use of statistical methods in the publication of medical papers The author found that there were statistical problems in many medical papers. Even in published articles, mistakes in the use of statistical methods are not uncommon.
Therefore, it is very important for scientific research and paper writing to master enough statistical knowledge and correctly use statistical methods in analysis. When publishing medical papers, please try to choose regular journals. The so-called regular publications refer to the collections of HowNet, Wanfang and VIP that can be found in the General Administration of Press and Publication.
The main publications of medical papers are as follows: Shandong Medicine (Chinese Core+Statistical Source Journal) China Journal of Practical Nursing (Chinese Core+Statistical Source Journal) Shizhen Traditional Chinese Medicine Ethnic Medicine China Maternal and Child Health Modern Preventive Medicine China Gerontology China Experimental Traditional Medicine Prescription Journal China Primary Medicine Qilu Nursing China Modern Doctors Clinical Medical Practice Asia-Pacific Traditional Medicine, Global Traditional Chinese Medicine, China Ethnic Folk Medicine, Henan Journal of Surgery, China Nursing Journal, China Health Care, Adolescent Health, China Modern Doctor, Chinese Medicine Guide, China Contemporary Medicine, China Chinese Medicine Consultation, Chinese and Foreign Medicine, Clinical Medical Practice, Clinical Research of Chinese Medicine, China Medical Innovation, Medical Information, Wish You Health, Clinical Medical Engineering, Clinical Medical Journal, Medical Care, Health. Rehabilitation Medicine, China Medical Guide, Chinese Medicine Management, China Modern Medicine, chinese medicine modern distance education of china, China Digestive Surgery, Journal of Clinical Rational Drug Use, Inner Mongolia Traditional Chinese Medicine, Everyone's Health, Clinical and Experimental Medicine, Jilin Medicine, Anhui Medicine, General Nursing, etc.
4. Published according to the title of medical papers.
1. There are many journals that publish papers on medical universities. First of all, you need to confirm the level of submission, whether it is a core, national or provincial journal. Different levels of journals have great differences in the innovation requirements and published length of articles; 2. Different journals have their own requirements about the format of medical papers. As long as your article is good enough, the format can be modified; 3. Generally speaking, it takes a long time for periodical publishers to review the titles of medical papers, ranging from half a year to one year.
If you need to publish the title of a medical paper quickly or feel that your article is not good enough, then I suggest you find a professional paper agency website, such as Thesis Times. They will modify your article accordingly, so as to ensure the rapid publication of the article, and it is very safe to open an appointment letter before paying. Good luck.