Are cephalosporins effective for mycoplasma and chlamydia infections? Why?
In the aspect of cellular immunity, most patients with active cured chlamydia often cause delayed allergic reaction when given the corresponding antigen intradermal injection. This allergic reaction can be passively transferred through lymphocytes. This immunity may be mediated by T cells. In humoral immunity, neutralizing antibodies appear in serum and local secretions after mycoplasma and chlamydia infection. Neutralizing antibodies can prevent chlamydia from adsorbing to host cells, and can also enhance the uptake of phagocytes through conditioning. 1. Mycoplasma is a pathogenic microorganism smaller than bacteria and larger than virus, which often causes respiratory infection through droplet transmission. Mycoplasma pneumonia is a kind of pneumonia that has attracted much clinical attention in recent years. Timely medication is effective and the treatment effect is good. Improper medication will not only aggravate the condition, but also cause serious complications such as encephalitis, meningoencephalitis, heart and liver damage. It must be emphasized that the antibacterial principle of penicillin and cephalosporin antibiotics commonly used to treat respiratory tract infections and pneumonia is to prevent cell wall synthesis. Mycoplasma has no cell wall. Therefore, these two drugs are "wrong" for mycoplasma pneumonia. 2. After mycoplasma and chlamydia infect human body, they first invade columnar epithelial cells, grow and reproduce in the cells, and then enter the cells of mononuclear phagocyte system to proliferate. Because mycoplasma and chlamydia multiply in cells, infected cells die, and at the same time, they can escape the immune defense function of the host and get intermittent protection. The pathogenic mechanism of mycoplasma and chlamydia is to inhibit the metabolism of infected cells, dissolve and destroy cells, lead to the release of lysozyme, the cytotoxic effect of metabolites, and cause allergic reactions and autoimmunity. The first choice for treatment of mycoplasma and chlamydia infection: Macrolide antibiotics (including azithromycin and erythromycin) are the first choice for mycoplasma infection. If you are allergic, you can also use pioneer drugs, such as cefradine, cefixime, and cefoperazone sodium and sulbactam sodium. For example, chlamydia simplex and mycoplasma are not pathological chlamydia, but normal flora in many parts of our body, such as eyes, nostrils, anus, mouth and vagina. As long as it is not big enough to cause symptoms (itching, unbearable swelling, fever, etc. ), that's not a disease, let alone need treatment. If a large number of antibiotics lead to dysbacteriosis, it will become pathological. But if the ratio exceeds normal, it will cause itching, pain, unbearable swelling, fever and so on. That is, chlamydia and mycoplasma inflammation, so it needs treatment. Macrolide drugs are effective, erythromycin and azithromycin are effective orally, and infusion is not needed. Therefore, most of the positive results of chlamydia and mycoplasma are not pathological, which only shows that vagina is normal, and cervical erosion is caused by high estrogen level, which has nothing to do with chlamydia. If repeated treatment may cause vaginal itching, it may be flora imbalance. Stop using all products and do not clean the vagina. After a week's observation, it will generally be good. If it is not good, do a colposcopy and bacterial culture, and then treat the cause, and the medicine will get rid of the disease. Follow-up: UU culture was positive, and drug sensitivity test was not done. B-ultrasound showed pelvic effusion of clarithromycin tablets; Twice a day, one 0.25mg Fuke Qianjin Capsule once; Is it effective to take two pills twice a day? Answer: Your prescription is not effective, and the treatment of chronic diseases is OK. If you want to treat it thoroughly, you'd better choose sensitive drugs and infusion treatment. Follow-up: Since "cephalosporins are ineffective against mycoplasma infection", why is it "the first choice for treating mycoplasma and chlamydia infection: pioneer drugs can also be used, such as cefradine, cefixime, cefoperazone and sulbactam sodium can be intravenously dripped"? English is the same, but the pioneer is transliteration. Answer: Hey, friend, I found that your knowledge is more professional than mine. How can I put it? Anyway, in this clinical situation, drug sensitivity tests are generally taken to guide drug use according to the results. In fact, most of the above viewpoints are in the paper, and they are all borrowed from each other. In order to treat diseases better, doctors also learn from each other in clinic. In particular, the previous scheme was adopted.