Professor Wu Guangning aims at ensuring the safe operation of traction power supply equipment in electrified railways, and studies the safe operation and state evaluation of electrical insulation in "train-catenary-substation" system. With the support of the National Natural Science Foundation and the "863" and "973" projects of the Ministry of Science and Technology, remarkable research achievements have been made in the insulation materials and technology of traction power supply equipment, the electrical insulation technology and state evaluation of high-speed EMU, and the overvoltage theory and protection technology of traction power supply system.

The research results are applied to high-speed and heavy-haul electrified railways such as Wuhan-Guangzhou Passenger Dedicated Line and Daqin Railway, which ensures the safe operation of traction power supply equipment. Won the National Science Foundation for Distinguished Young Scholars, the second prize of National Science and Technology Progress Award (ranking 1), the first prize of Sichuan Science and Technology Progress Award (ranking 1), the first prize of China Railway Society (ranking 2) and the first prize of Chengdu Science and Technology Progress Award (ranking1). Five invention patents and three utility model patents were authorized; Published 228 academic papers, of which 168 were included in SCI/EI.