After oral administration, the drug is rapidly absorbed and hydrolyzed from gastrointestinal tract to clindamycin, and the absorption rate is about 90%, and the absorption is not affected by food. The peak blood concentration is about 65438 0 hours (according to clindamycin, children take 2-4mg/kg orally every 6 hours, and the blood concentration can reach about 2-4 mg/L; Adults take 150-300mg each time, and the blood concentration can reach about 2.5-4mg/L). The binding rate between drugs and plasma protein is higher, reaching more than 60%, about 2 hours for children with t 1/2 and about 2.5h hours for adults. The half-life can be prolonged when liver and kidney function is impaired. After absorption, the drug is quickly and widely distributed in all tissues and body fluids except cerebrospinal fluid, and its concentration is high in liver, kidney, spleen, bone, bile and urine (the drug with 46% blood concentration in the mother can enter the fetal blood circulation through the placenta and form a high concentration in the fetal liver). Clindamycin is metabolized in the liver to produce N- norclindamycin and clindamycin sulfoxide, which have antibacterial activity. Drugs and their metabolites are excreted through kidney, bile, intestinal juice and milk. The 24-hour excretion rate in urine is 10%, and in stool it is about 4%. No drug accumulation or metabolic changes were found after repeated medication.