2. Study on the role of sialic acid Lewis X in breast cancer and its regulatory genes, Zhejiang Returnee Fund, 1998-2000.
3. International Randomized Controlled Multicenter Clinical Treatment of Early Breast Cancer (Chinese and English): Head of Zhejiang Province, 1992-2002.
4. The role of SNC19 in liver metastasis of colorectal cancer and screening of metastasis-related functional proteins: National Natural Science Foundation, ranked first. Project approval number: 30200325. Funding amount: 220,000 yuan. 2003. 1-2005. 12.
5. Participate in scientific research projects: early diagnosis and early treatment of colorectal tumors (national key project in the Eighth Five-Year Plan and the Ninth Five-Year Plan, responsible for comprehensive investigation of fibercolonoscopy in high-risk groups in Haining).
6. Clinical study on the feasibility of laparoscopic-assisted radical resection of rectal cancer: Zhejiang Natural Science Foundation, ranked first. Project approval number: X206953. Funding amount: 20,000 yuan. 2007. 1-2008. 12
7. Drug resistance mechanism, new drug screening and treatment strategy of gastrointestinal stromal tumors. Zhejiang Science and Technology Fund, ranked first. Project approval number: 2007c33089. Funding amount: 50,000 yuan. 2007.6-2009. 12
8.hbex2 promotes the screening and functional identification of key target molecules downstream of apoptosis induced by imatinib. National natural science foundation, ranked first. Project approval number: 30772473. Funding amount: 300,000.2008.438+0-2004.38+00.438+02.
9. Establishment and standardization of comprehensive treatment mode of accelerated rehabilitation surgery for colorectal cancer. Zhejiang province ranks first in major science and technology projects and key social development projects. Project number: 2009C 130 17, funding amount: 600,000.071-2012.12009.
10. Identification of hBex 1, a new shuttle molecule involved in endoplasmic reticulum stress and mitochondrial-related apoptosis in the process of acquired drug resistance of tumor cells, won the first place in the National Natural Science Foundation of China. Project approval number: 8 107 180 1. Funding amount: 330,000. 20 1 1. 1-20 13. 12
1 1. Bcr/Abl+ identification of a new apoptosis shuttle molecule hBex 1 in the process of acquired drug resistance of tumor cells, and it won the first place in the Outstanding Youth Fund of Zhejiang Natural Science Foundation. Project number: R2 10007 1, funding amount: 300,000 yuan, 20 10.6-20 13.6.
12. The key subject project of health innovation in Zhejiang Province, Early Warning Intervention and Comprehensive Diagnosis and Treatment of Colorectal Cancer, ranked first. Funding amount: 300,000 yuan 2011.1-2014.1.
13. Study on the mechanism of promoting apoptosis and reversing drug resistance of a new tumor drug resistance-related protein Bex 1. National natural science foundation, ranked first. Project approval number: 8 1272455, funding amount: 700,000. 20 13. 1-20 16. 12
14. Study on technical specifications of minimally invasive surgery for gastrointestinal tumors. 20 14 public welfare fund for health industry. Ranked first. Project approval number: no. 20 14020 15. Funding amount: 654.38+200,000. 20 14. 1-20 16. 12
Study on the effect, mechanism and transformation of BEX 1 in inhibiting liver metastasis of colon cancer. Supported by the National Natural Science Foundation, ranked first. Project approval number: 8 1472664, funding amount: 650,000. 2015.1-2018.121,A comparative study of conventional and fast-track multidisciplinary treatment interventions for colorectal cancer. ClinicalTrials.gov identifier: NCT0 1080547.
2. Randomized trial (PSSR) of early surgical treatment of MRI-negative CRM rectal cancer after selective radiotherapy and chemotherapy. ClinicalTrials.gov identifier: NCT02 12 1405.
3. To evaluate the experiment of hot intraperitoneal chemotherapy (HIPEC) in the treatment of high-risk patients with peritoneal metastasis of colorectal cancer. ClinicalTrials.gov identifier: NCT02 179489.
4. To compare pouch suture and involuntary suture in the study of colostomy reversal in patients with colored cancer. Clinical trial GovIdentifier: NCT 02564224 (first author or correspondent).
Papers included in SCI
1, Xu D, Li J, Song Y, Zhou J, Sun F, Wang J, Duan Y, Hu Y, Liu Y, Wang X, Sun L, Wu L, Ding Kefeng. In patients with colorectal cancer, laparoscopic surgery is more helpful for nutrition and immune recovery than rapid rehabilitation. World journal of surgical oncology. 2015 February 4th; 13( 1): 18.
2. The signet ring cell components of Tan Y, Fu J, Li X, Y Ang J, Jiang M, Ding K, Xu J, Li J and Yuan Ya minor (& lt50%) are related to the poor prognosis of colorectal cancer patients: a 26-year retrospective study in China. Public library of science no.1. 20 15 Mar 19； 10(3):
3. Li? , gold? Shao? Jing? Where is the sword? , Li Jun, Yong? Mao Song, Ke? Ding Feng and Shu Zheng. Sacrectomy with pre? Surgical treatment and approach of rectal gastrointestinal stromal tumor with imatinib mesylate: report of 2 cases. Oncology Express 2014,8:1455-1460.
4,,, Jiao Yurong,,, Yi,,, Hu Mo Lifeng, Qian Xiao, Li Jun, Ding Kefeng. Neuroendocrine differentiation is a prognostic factor for stage II poorly differentiated colorectal cancer. Biomedical research, 20 14.
5. Jian, Ye, Jin, Yu Xiuyan, Han, Ying Yuan, Su, Ding Kefeng. Oxaliplatin-based adjuvant chemotherapy without radiotherapy can improve the survival rate of locally advanced rectal cancer. Public library of science no.1. 20 14
, Bao, Jian, Fu Xianhua, Su, Preston, Ke. TNM staging of colorectal cancer should be reconsidered by weighted T staging. World Journal of Gastroenterology. 2014 may 7th; 20( 17): 5 104-5 1 12
7. Xiao Qiang, Hu Yutao, Liu Yan, Wang, Geng Haitao, Hu Lifeng, Xu Di, Wang K, Zheng L, Zheng S and Ding. BEX 1 promotes apoptosis induced by imatinib by binding and antagonizing BCL-2. Public library of science no.1. 20 14 (in print)
8. Wang, Ding, Yu Jiguo, Zhai, Ruan Xiaoping, Wang Southwest, Zhu, Zheng S, Zhang Sicheng. Using sel di- protein chip platform, the protein omics of primary colon cancer-related fibroblasts was analyzed. Bachelor of Science, Zhejiang University; 13: 159- 167.
9. He, Ding, Zheng, Xu, Li Jun, Wu, Sun Lifeng, Zhou De, Zheng. Squamous cell carcinoma of pancreatic uncinate gland with gastric synchronous gastrointestinal stromal tumor: a case report and literature review. Oncol letter 4:1191-194,2012.
10, Zhou, Li Jun, Ying, Song, Chen R, Chen G, Min Y, Ding. Comparison between fast multidisciplinary therapy (FTMDT trial) and conventional therapy for colorectal cancer —— Design of a prospective randomized controlled study. BMC cancer. 20 1 1; 1 1:494-505.
1 1, Li Jun, Wang, Zheng S, Zhang Shizhong, Ding. Effect of laparoscopic surgery on metastasis gene expression of colorectal cancer: gene chip analysis report and literature review. Hepatogastroenterology. 20 1 1; 12: 1975- 1982。
12, Ding, Ying, Li Jun, Li Gang, Chen, Wang, Lu Kai, Zhou, Ma, Zhang Sizhe. Mid-term analysis of an open non-randomized prospective study comparing laparoscopic surgery with XELOX chemotherapy and open surgery with mFOLFOX6 chemotherapy for resectable colorectal cancer. Yearbook of Oncology. 20 10; 2 1:220. Supplement 8
13, Li Jun, Chen Rijun, Xu Yongqiang, Wang, Zheng Sheng, Zhang Shizhong, Ding. Effect of laparoscopic resection on quality of life of patients with rectal cancer: 135 results. Surgery today. 20 10; 10: 9 17-922.
14, Ding, Su, Pang Ruolong, Lu Qing, Wang, Zhang Shizhong, Zheng Sheng, Mao Jiansheng, Zhu. Inhibition of apoptosis by down-regulating hBex 1 is a new mechanism of chemotherapy resistance of Bcr/Abl+ leukemia cells. Carcinogenesis. 2009; 30:35-42.
15, Ding, Chen R, Zhang, Li J, Xu Yongqiang, Lu L, Wang, Sun Lifeng, Wang, Zheng S, Zhang SZ. Laparoscopic surgery for rectal cancer: results of a case-control study in three centers in China. 2009,23:854–86 1.
16, Sun Lifeng, Ye Hailin, Zhou, Ding, Qiu Peilin, Deng, Zhang Sixiang, Zheng Sheng. Giant Hemangiolymphangioma of Pancreas in a 20-year-old girl 1 Case Report and Literature Review. World journal of surgical oncology. 2009; 18:3 1-33.
17, Zhou, Wei, Ding. A rare case of metachronous bilateral breast angiosarcoma. Breast Nursing in 2009; 4:405-407
Protein interaction analysis of 18, Ge WT, Hu HG, Ding, Sun Lifeng, Zheng S ST14 domain and its point mutation and deletion mutation. Journal of Biochemistry. 2006; 28 1:7406-74 12.
Expression, purification and activity determination of tumor metastasis-related protein ST 14. FEBS j . 2005； 272: 352-352. Supplement 1
20. Ding, Sun Lifeng, Ge Weidong, Hu Haigang, Zhang Shizhong and Zheng Sheng. Effect of over-expression of SNC 19/ST 14 gene on invasion ability of colorectal cancer cells. World Journal of Gastroenterology. 2005; 36:565 1-5654.9
2 1, Akio Yamaguchi, Ding Kefeng, Maehara Masanori, Takazawa Takei and Ji Zang Nakagawa. Expression of nm23-H 1 gene and sialylated Lewis X antigen in breast cancer. Oncology, 1998, 55:357-362.
22. Ding Kefeng, Tsuyoshi Yamaguchi Fu, Takei Lund, Maehara Masanori and. Gizzo Nakagahara. Study on lectin histochemical reactivity of sialic acid in breast cancer with limulus lysate and its relationship with prognosis. Journal of international oncology, 1997, 10:759-763.
Papers included in China Biomedical Literature Database;
1, He Jinjie, Ding Kefeng, Quality control of laparoscopic colorectal surgery. Chinese Journal of Gastrointestinal Surgery, 20 15, 18 (8): 19-22.
2. Sun, Ding Kefeng. Surgical tumor cell inactivation combined with intraperitoneal hyperthermic perfusion chemotherapy-the breakthrough direction of peritoneal metastasis of colorectal cancer? Chinese Journal of Colorectal Diseases, 2015,4 (3) 234-239.
3. Geng Haitao, Xiao Gan, Xu, Hu and Ding Kefeng. Construction of recombinant lentiviral vector HNF6 and its effect on invasion and metastasis of colorectal cancer SW620 cells. Journal of Southern Medical University, 20 12, 32:66-70.
4. Chen Guoqing, Li Junhe Dink Peak. Meta-analysis of the safety of primary and secondary liver metastases from colorectal cancer. Chinese Journal of Gastrointestinal Surgery, 20 10, 13: 337-34 1.
5. Sun, Ding Kefeng, Zhou Qiyan, Zhang Suzhan, Zheng Shu. ST 14/MT-SP 1 affects the expression of MT2-MMP and TIMP-2 and enhances the invasion of colorectal cancer cells. China Journal of Pathophysiology, 2008, 24:2356- 2362.
6. Ding Kefeng, Sun, Wang Jianwei and Zhang Suzhan. Evaluation of quality of life in patients with rectal cancer after laparoscopic surgery. Journal of Zhejiang University (Medical Edition), 2007, 36:37 1-377.
7. Sun, Ding Kefeng, Wu, Peng Jiaping, Zhang Suzhan and Zheng Shu. Relationship between the expression of PTEN and Her-2 and the prognosis of breast cancer. China Journal of Pathophysiology, 2006, 22:2380-2384.
8. Li Jun, Ding Kefeng and Zhang Suzhan. Meta-analysis of short-term efficacy and safety of patients with colorectal cancer after laparoscopic surgery. Chinese medical journal, 2006, 86:2485-2490.
9. Sun, Zheng Shu,,, Ge Weiting, Ding Kefeng. Effect of SNC 19/ST 14 expression on biological behavior of colorectal cancer cells. China Journal of Medicine, 2004, 84:843-848.
10, Ding Kefeng, Zheng Shu. Relationship between fucosyltransferase gene subtypes and metastasis and prognosis of breast cancer. China Journal of Surgery, 2004, 42:546-550.
1 1, Wang Jueji, Ding Kefeng, Chen Lirong. Diagnosis and clinicopathological analysis of 32 cases of gastrointestinal stromal tumors. China Journal of General Surgery, 2004, 19:340-342.
12, Ding Kefeng, Shi Yulan, Zhang Suzhan. A randomized controlled study on wound management of improved radical mastectomy. Chinese Journal of General Surgery, 2004, 19:497-498.
13, Ding Kefeng, Wu. Relationship between sialic acid glycogen molecule and nm23-H 1 gene expression and metastasis and prognosis of breast cancer. Journal of Zhejiang University (Medical Edition). 2004,33(4):326-330。
14, Ge Weiting, Sun, Ding Kefeng. Expression, purification and activity identification of tumor metastasis-related protein ST 14. China Journal of Biochemistry and Molecular Biology, 2004, 20:685-689.