In the evaluation of Nature sub-journals, if two positive and one negative evaluation results are obtained, it means that the evaluation of two reviewers is positive, while the evaluation given by another reviewer is negative. In this case, the editor usually gives you a chance to revise it, which is also an opportunity for you to show your research results and the quality of your paper.

Whether or not to accept the paper depends not entirely on the opinions of the reviewers, but also on the judgment of the editors. If editors have a positive view of the overall research and the importance of research, they may accept the paper, even if a reviewer has a negative opinion. However, if the editor's confidence in the paper is low, or they think that negative opinions pose a major challenge to the quality or importance of the paper, the paper may be rejected.

In this case, if you think the editor's decision is unfair or based on inaccurate information, you have the right to appeal or appeal. But this requires you to provide sufficient reasons and evidence to support your point of view, and the editor may also ask you to make further revisions and explanations.

Generally speaking, although two positive and one negative evaluation results are not the best situation, you still have the opportunity to improve the quality and persuasiveness of the paper through revision and explanation, thus increasing the chances of being accepted.