In the annual defense, many students need to write their own opinions and the opinions of their tutors. The following are my comments on the evaluation of medical master's thesis, which are for your reference only and I hope to help you.
Study on the influence of Guben Huoxue method on inflammatory factors in COPO patients
On the basis of predecessors' work, this paper observed the blood circulation and the expression of inflammatory factors IL-8 and ICAM- 1 in patients with chronic obstructive pulmonary disease (COPD) by clinical standard methods, and discussed its mechanism. The results show that the method of promoting blood circulation and removing blood stasis can inhibit the release of inflammatory mediators, improve mucosal edema and lumen obstruction, inhibit interstitial cell proliferation and smooth muscle thickening, and block airway reconstruction, which is the mechanism of consolidating the fire and snow effect. Preliminary comments are as follows:
1, the paper can integrate theory with practice, start with solving key clinical problems, explore relevant treatment mechanisms, and draw reliable conclusions, which has strong theoretical significance and practical value, and has certain innovation.
2. The project design conforms to the essence of TCM theory, with advanced technical methods, reliable data and convincing conclusions. It shows that the author has basically mastered the development direction and main documents in this field, can stand at the forefront of contemporary clinical medicine to carry out research and theoretical exploration, has the ability to independently engage in scientific research of traditional Chinese medicine, has a solid foundation in this subject and solid operational skills, and basically meets the requirements of master students.
3. The writing of the paper is standardized, the statistical method is correct, the logical structure is clear, and the written expression is fluent. It is suggested to arrange a master's degree thesis defense.
4. If we can further carry out multi-center and large-sample randomized double-blind controlled trials, the conclusion may be more valuable.
Comment 2 on the Effects of Astragalus Polysaccharide on Serum IL-4, IL-5 and IL- 13 in Ulcerative Colitis Model Rats
In this paper, the rat model of ulcerative colitis was used to observe the immunomodulatory effect of Astragalus polysaccharide. The results suggest that the pathogenesis of ulcerative colitis may be related to the abnormality of serum IL-4, IL-5, IL- 13 and IgG. Astragalus polysaccharide can play a therapeutic role by increasing IL-4, IL- 13 and decreasing IgG, and it can repair and regulate the intestinal mucosal immune system in rats with ulcerative colitis. The review comments are as follows:
1. This study starts with solving key clinical problems, with reasonable design, advanced indicators, standardized operation, correct statistical methods and reliable data. It has strong theoretical significance and practical value, and has certain innovation.
2. At present, although Chinese medicine has done a lot of work and made progress in the prevention and treatment of ulcerative colitis, the clear clinical efficacy, in-depth mechanism research and systematic theoretical summary are still obviously insufficient, and the phenomenon of low-level repetition is serious. The author of this paper has mastered the solid and extensive basic theory and solid operation skills of this major, extensively collected the latest progress at home and abroad, and successfully studied the immunomodulatory effect of Astragalus polysaccharides, which shows that the author can stand at the forefront of contemporary Chinese medicine research and carry out scientific research independently.
3. The writing of the thesis is standardized, the statistical method is correct, the logical structure is clear, and the written expression is fluent, which basically meets the requirements of master students. It is suggested to arrange a master's degree thesis defense.
The third review of medical master's degree thesis: Based on protein's omics, this paper discusses the simultaneous effects of Fuzheng Huayu recipe on liver and kidney fibrosis.
Protein omics is the frontier field of contemporary biological science, which clarifies the pathogenesis and drug targets of diseases at the level of multi-protein network. On the basis of previous work, this paper compared the intervention effect and mechanism of Fuzheng Huayu recipe on liver and kidney fibrosis through protein expression spectrum analysis, mass spectrometry identification and differential protein function analysis, and found that regulating substance metabolism, oxidative stress, cytoskeleton protein and other related proteome is one of the * * * synergistic mechanisms of Fuzheng Huayu recipe in treating liver and kidney fibrosis. It is further proved that the regulation of collagen metabolism by this recipe is characterized by up-regulating interstitial collagenase activity, promoting abnormal deposition collagen degradation, down-regulating basement membrane collagenase activity and protecting normal basement membrane structure. The preliminary examination opinions are as follows:
1. The subject studies the simultaneous action characteristics of Fuzheng Huayu recipe on liver and kidney fibrosis through protein omics, which is in line with the essence of TCM theory, innovative in design, advanced in technical methods, basically reliable in data, and convincing in conclusion, and it is a pioneering achievement of TCM anti-fibrosis research.
2. The author of this paper has the ability to independently engage in scientific research of integrated traditional Chinese and western medicine, has mastered the development direction and main documents in this field, can stand at the forefront of contemporary biology to explore technologies, methods and theories, meets the basic requirements of doctoral students of integrated traditional Chinese and western medicine, and has a solid foundation and practical skills in this subject.
3. The writing of the paper is standardized, the statistical method is correct, the logical structure is clear, and the research ideas are worth popularizing. It is suggested to arrange a defense as a doctoral thesis.
4. Based on this, it may be more meaningful to further study the protein omics differences of this prescription in anti-hepatic and renal fibrosis, and make corresponding analysis and evaluation.
Inhibitory mechanism of salvianolic acid B salt on endothelin-induced contraction of rat hepatic stellate cells
On the basis that sa-b can effectively reverse hepatic fibrosis and inhibit et- 1-induced portal hypertension in rats and contraction of human and rat HSC5, this paper systematically studied the molecular signal mechanism of Ca2+-mlck and ROCK pathways in the process of contraction of rat HSC5 stimulated by et- 1, and the inhibitory effect of sa-b on contraction of rat HSC5 induced by et- 1
1. It is a useful attempt to study the inhibitory effect of SA-B on the contraction of HSC5 induced by ET- 1 from the molecular signal mechanism. The research project has reasonable design, advanced indicators and strong demonstration. It's a good article combining traditional Chinese and western medicine.
2. Being able to engage in research from this depth shows that the author has stepped into the forefront of this field and basically mastered the development trend and main literature materials within the scope of this course. On the one hand, it reflects that the author has mastered the solid and extensive basic theory and solid operational skills of this subject. On the other hand, it shows that the author has the ability to engage in scientific research of integrated traditional Chinese and western medicine independently and is a qualified doctoral student.
3. The writing of the paper is standard, the calculation data is reliable and the logical reasoning is correct. It is suggested to arrange a defense as a doctoral thesis.
4. At the beginning of the third section of the introduction, "HSC5 has the ability to contract or relax a variety of vasoactive substances, among which endothelin-1 (ET- 1) has the strongest effect", which needs to be corrected.
Just now, I dug up the evaluation of four doctoral theses in Shanghai last year and put them here for data preservation.
The fifth part: blocking the "crosstalk" between TGF-β 1 in HSC signal pathways, and studying the mechanism of salvianolic acid B's anti-hepatic fibrosis effect.
This topic uses RNAi technology and signal pathway blockers to block the "crosstalk" between pathways, and studies the anti-hepatic fibrosis mechanism of salvianolic acid B, which is one of the rare high-level doctoral dissertations I have seen. No matter from the technical method or project design, it embodies the frontier in this field at present and the rigorous and realistic characteristics of contemporary scientific research.
At present, Chinese medicine has done a lot of work to prevent and treat liver diseases, but the phenomenon of low-level repetition is more serious, and the rigor of project design and research depth are obviously insufficient. Under the guidance of the tutor, the author studied the anti-hepatic fibrosis mechanism of salvianolic acid B on the premise of mastering the solid basic theory and operation skills of this major, and on the basis of the preliminary research of salvianolic acid B, by blocking the "crosstalk" inside MAPK pathway and the "crosstalk" between Sand, ERK and p38 signals, and obtained more accurate experimental data, which marked a new step in the modernization of traditional Chinese medicine. This study embodies the following ideas:
(1) With the latest achievements and theories of modern medicine, the research level of traditional Chinese medicine is close to the latest frontier; (2) Eliminate all kinds of interference factors that affect the result analysis as much as possible, and look for the uniqueness or repeatability of the research conclusion; (3) Pay attention to the logic of project design and paper summary.
The research is rigorous in design, advanced in technology, standardized in operation, reasonable in statistics and reliable in data. The paper is standard in writing, strong in logic, clear in structure and fluent in writing. It is suggested to arrange a defense as a doctoral thesis.
Evaluation opinion of medical master's degree thesis 6 Study on the pathogenesis of prescription syndrome in rats with liver cirrhosis induced by dimethylnitrosamine
In this paper, the intervention effect of five classical prescriptions and the effective prescriptions were studied by using dimethylnitrosamine liver cirrhosis model. Heavy workload, advanced indicators, reasonable design, standardized operation, strong logic, reliable data, clear paper structure and smooth text expression. It is suggested to arrange a defense as a doctoral thesis.
Using comparative medicine to study the "disease-syndrome-prescription" effect of classic prescriptions in preventing and treating liver cirrhosis is a research idea with Chinese medicine characteristics. On the basis of the previous work, the author has basically mastered the solid basic theory and operation skills of this major, extensively collected the latest progress at home and abroad within the scope of this topic, and obtained the experimental data and mechanism of different prescriptions to interfere with liver cirrhosis, which shows that the author can stand at the forefront of the current research on traditional Chinese medicine for liver diseases and have the ability to independently engage in traditional Chinese medicine research.
Due to the rush of time, some styles in the paper are still not unified. It is suggested that after "Materials and Methods" (the first and second parts are merged), the research results should be divided into three parts, so that the style of the whole paper is consistent.
Chapter VII Influence of Eliminating Dampness and Removing Blood Stasis Method Based on Uniform Design on Different Action Pathways of Experimental Fatty Liver: A Study of Traditional Chinese Medicine
In this paper, the experimental study on the prevention and treatment of fatty liver in vivo and in vitro was carried out by using the mathematical model "uniform design method", which explored a new way for the study of compound pharmacology, an important frontier of Chinese medicine modernization, provided convincing experimental data for clarifying the compatibility and mechanism of Chinese medicine, and laid the foundation for further optimizing the formula, improving the curative effect and developing high-tech new drugs.
The research design is reasonable, the index is advanced, the operation is standardized, the statistical method is correct and the data is credible. The thesis is standard in writing, reliable in logical reasoning and fluent in expression, and it is a high-level doctoral thesis. It is suggested to arrange a defense as a dissertation.
At present, although a lot of work has been done and progress has been made in the research on prevention and treatment of liver diseases by traditional Chinese medicine, the clear clinical efficacy, in-depth mechanism research and systematic theoretical summary are still obviously insufficient, and the phenomenon of low-level repetition is serious. The author of this paper has mastered the solid and extensive basic theory and solid operation skills of this major, extensively collected the latest progress at home and abroad within the scope of this topic, and successfully applied the "uniform design method" to the study of compatibility effect and mechanism of traditional Chinese medicine in preventing and treating fatty liver, which shows that the author can stand at the forefront of contemporary Chinese medicine research and carry out scientific research independently. If the subject is strengthened in pharmaceutical research (such as source identification and quality control, etc. ), the data will be more convincing.
Effects of Fuzheng Huayu recipe and salvianolic acid B on TGF-β 1 in anti-hepatic and renal fibrosis.
On the basis of predecessors' work, aiming at the important signal transduction pathways (TGF-β 1, TβR/Smads pathway) in the process of liver fibrosis, this paper comparatively studies the important mechanisms of Fuzheng Huayu recipe and salvianolic acid B in resisting liver fibrosis and renal interstitial fibrosis, further explains the scientific connotation of "treating different diseases at the same time" in traditional Chinese medicine, and provides a typical example for the modernization research of traditional Chinese medicine.
As can be seen from the paper, the author has basically mastered the solid basic theory and operation skills of this major, extensively collected the development direction and main literature within the scope of this topic, and obtained the experimental data of the influence of Fuzheng Huayu recipe and salvianolic acid B on TGF-β 1 transduction, which shows that the author can stand at the forefront of contemporary Chinese medicine liver disease research and independently carry out scientific research on the combination of traditional Chinese and western medicine.
Although liver fibrosis and renal interstitial fibrosis belong to different organ diseases, the mechanism of their occurrence and development is the same. The author observed and compared the effects of Fuzheng Huayu recipe and salvianolic acid B on important signal transduction pathways, and clarified their mechanisms. The subject design is rigorous, the indicators are advanced, the operation is standardized, the statistics are correct, the data are reliable, the reasoning is logical, the structure level is clear, and the text expression is smooth. It is suggested to arrange a defense as a doctoral thesis.
Basic study on protein group effect of different classical prescriptions on liver tissue in rats with dimethylnitrosamine cirrhosis
It is the frontier field of modernization of traditional Chinese medicine to study the anti-hepatic fibrosis effect of traditional prescriptions by using protein omics. On the basis of previous work, this paper compared the effects of Yinchenhao decoction, Xiayuxue decoction, Huangqi decoction, Yiguanjian decoction and Xiaochaihu decoction on protein changes in liver tissue of rats with dimethylnitrosamine cirrhosis, and found that regulating abnormal cell proliferation and apoptosis and antioxidant stress injury were the mechanisms of Yinchenhao decoction in inhibiting the formation of dimethylnitrosamine cirrhosis and improving protein and amino acid metabolism in rats. Inhibition of abnormal cell differentiation, antioxidant stress and mitochondrial damage is the main link of Huangqi decoction to slow down the process of liver fibrosis and improve the abnormal metabolism of neurotransmitters, fat and sugar. The preliminary examination opinions are as follows:
1. In this paper, the effects of different classical compound prescriptions on protein group in liver tissue of rats with liver cirrhosis caused by dimethylnitrosamine were studied by protein omics, which accords with the essence of Chinese medicine theory, is innovative, advanced in technical methods, reliable in data, convincing in conclusion and has groundbreaking results.
2. The author has basically mastered the development direction and main literature in this field, can stand at the forefront of contemporary biology to explore technologies, methods and theories, and has the ability to independently engage in scientific research of integrated traditional Chinese and western medicine. The subject has a solid foundation and solid operational skills, which basically meets the requirements of doctoral students.
3. The writing of the paper is standardized, the statistical method is correct, the logical structure is clear, and the written expression is fluent. This research idea is worthy of further promotion and verification. It is suggested to arrange a defense as a doctoral thesis.
4. If multiple models can further verify the above results, it may be more valuable to compare the data differences of different models.
Comments on Medical Master's Dissertation 10 Research on Optimization of Mixed Demand VRP Problem Based on Genetic Algorithm
Have solid basic theoretical knowledge and professional knowledge; Be able to design the experimental scheme correctly (or establish the mathematical model and mechanical structure scheme correctly); Conduct experimental work independently; Be able to use the knowledge and skills learned to find and solve practical problems; Can correctly handle experimental data; Be able to analyze the subject theoretically and draw valuable conclusions; Have a good professional foreign language level paper quality.
The summary is concise, complete and insightful; The argument is correct, the discussion is sufficient, and the conclusion is rigorous and reasonable; Correct experiment, scientific analysis and treatment; Fluent writing, accurate terminology, unified symbols, complete numbers, neat and standardized handwriting, complete, neat and correct charts; The results of the paper have application value; The calculation and test results are accurate; Have a sense of innovation in work; Have improved or broken through the previous work, or have original opinions;
Comments on Master of Medicine Thesis 1 1 Title: Optimization of VRP Problem with Mixed Demand Based on Genetic Algorithm.
Evaluation content evaluation index
Thesis proposal
Able to independently consult documents and engage in other research; Be able to translate foreign language materials correctly; Be able to present the opening report of the subject well; The correctness of comprehensive analysis and design calculation; Adequacy of argument
Vocational skills
Have solid basic theoretical knowledge and professional knowledge; Be able to design the experimental scheme correctly (or establish the mathematical model and mechanical structure scheme correctly); Conduct experimental work independently; Be able to use the knowledge and skills learned to find and solve practical problems; Can correctly handle experimental data; Be able to analyze the subject theoretically and draw valuable conclusions; Have a good professional foreign language level.
Paper quality
The summary is concise, complete and insightful; The argument is correct, the discussion is sufficient, and the conclusion is rigorous and reasonable; Correct experiment, scientific analysis and treatment; Fluent writing, accurate terminology, unified symbols, complete numbers, neat and standardized handwriting, complete, neat and correct charts; The results of the paper have application value; The calculation and test results are accurate; Have a sense of innovation in work; Have improved or broken through the previous work, or have original opinions;
Workload and working attitude
It is difficult to complete the specified tasks on schedule due to full workload; Work hard and observe discipline; Work style is rigorous and pragmatic
Tutor's comments
This paper introduces the mixed demand VRP problem of distribution problem and delivery problem, and designs the corresponding genetic algorithm. Through C language programming, the experimental results show that the designed genetic algorithm is feasible and effective.
The topic of this paper has certain theoretical value and practical significance, with reasonable structure, clear logic and standard format.
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