Combined with the difference in inducing immune response between common antigen and superantigen, why is the mortality rate of sars higher than that of common influenza?

For simplicity, superantigen is labeled as A, and common antigen is labeled as B. ..

1. chemical properties: a includes bacterial exotoxin and retrovirus protein; B Including common protein, polysaccharide, etc.

2.MHC binding site: A is the non-polymorphic region, and B is the peptide binding groove in the polymorphic region;

3.TCR binding sites: A is Vβ, B is Vα, Jα, Vβ, Dβ, J β;

4.MHC restriction: A has no, B has;

5. Reaction characteristics: A directly stimulates T cells, and B needs APC treatment to be recognized by T cells;

6. Reactive cells: CD4+T cells, and B are T and B cells;

7.t cell reaction frequency: A is 1/20~ 1/50, and B is1106 ~104.

The above information is extracted from the notes of medical immunology, hoping to help you! ~~