A complex thing often contains simple rules, and there are rules to follow whether studying or doing scientific research. These laws are scattered in a large number of documents, waiting for people to explore. But it takes time and understanding to dig, and clinicians are afraid that they will but can't.
Friends who are interested in making innovations in disease objects, if there are not enough samples, observable objective indicators and repeatable in vitro and in vivo models, the initial difficulty is enough to make you flinch.
Now that the disease has been fixed, we should consider what phenotype to do next. As for how to link diseases with phenotypes, we need to dig out information from the reviews in recent five years and the projects of the National Natural Fund, and have an overall understanding of the fields to be studied.
Usually, the research object of medical scientific research is limited to diseases, and the basic idea of research is to analyze the phenotype (some physiological/pathological process) behind diseases, explain the pathogenesis and find the means of diagnosis and treatment. Therefore, doctors' scientific research often differs from disease to phenotype.
Once the phenotype is defined, the model also belongs to a general relevance. Because the model can visualize the abstract phenotype, it becomes a problem of cell, animal model and tissue specimen selection, which is transformed into experimental data and charts. Therefore, the constants of the model should be grasped quickly in the early stage of scientific research.
In order to learn the common sense of the model quickly, we can search the classic high-scoring research works for intensive reading after selecting the phenotype, and refine the phenotypic evaluation criteria used in the article, including the model, induction conditions, detection indicators, experimental methods, etc., so as to get the experimental design routine.
Then, with the help of master's thesis, we can understand the details of the experiment to improve the efficiency of extracting key information. Then just do it. As for more operational skills in the literature, we can only experience them in practice.