The safe dosage of paliperidone sustained-release tablets varies according to the specific conditions of patients, including age, weight, severity of illness and other factors. Generally speaking, the recommended initial dose for adults is 6mg once a day and taken in the morning. Some patients may benefit from a higher dose, such as 12 mg/day, while a lower dose of 3 mg/day is enough for some patients. When it is necessary to increase the dose, it is recommended to increase the dose by 3mg/ day at a time, and the interval between adjusting the dose should generally be more than 5 days. The maximum recommended dose should not exceed12mg/day.

For adolescent schizophrenics with age 12- 17 and weight ≥29Kg, the initial dose is suggested to be 3mg 1 time per day. Similarly, the dose increase should also be carried out after clinical evaluation, with an increment of 3mg/ day and an interval of more than 5 days.

For patients with impaired renal function, individualized dose adjustment is needed according to renal function. The maximum recommended dose for patients with mild renal damage is 6mg once a day, while the maximum recommended dose for patients with moderate and severe renal damage is 3mg once a day. For patients with liver injury, patients with mild to moderate liver injury usually do not need to adjust the dose.

Please note that paliperidone sustained-release tablets must be used under the advice and guidance of a doctor, and the dosage shall not be increased or decreased. At the same time, the drug concentration in blood should be monitored regularly to ensure the effectiveness and safety of drugs. If you have any discomfort or questions, please consult a doctor in time.