Pagetdisease was originally described as Paget's disease of the breast, and later it was found that other parts such as anus and vulva skin can also occur. Microscopic examination is characterized by many Paget's cells with large volume, round nucleus and transparent cytoplasm in the epidermis, that is, cancer cells.

Most of the patients are elderly women, and the most common parts are labia majora and labia minora and around anus. There is itching and burning pain locally. The diseased skin is bright red and erosive, with white skin islands in between, clear boundary, slightly higher than the skin surface, with fine particles on the surface, and often oozing and scabbing. The diagnosis of this disease is clear, and it needs to be differentiated from vulvar eczema, vulvar squamous epithelial carcinoma in situ, malignant melanoma and Bowen papulosis. Eczema vulvae belongs to chronic dermatitis, which can form blisters or bullae with lymphocyte infiltration without cancerous infiltration and metastasis. Squamous cell carcinoma of vulva in situ can also have eczema-like changes of vulva, but the course of disease progresses slowly and the prognosis is better than Paget's disease. The skin of malignant melanoma generally does not have eczema-like changes, and large round tumor cells with transparent cytoplasm can also appear in the lesions, and malignant cells can be seen, which can invade the epidermis. However, most malignant melanoma contains melanin, which is not difficult to distinguish according to clinical findings. Bowenoid papulosis is difficult to distinguish from this disease and squamous cell carcinoma in situ under microscope, but Bowenoid papulosis often occurs in young patients with consistent cell morphology, spontaneous regression tendency and good prognosis.