From the second year of Jin Yongxing (305) to the first year of Yongjia (307), Chen Min, the general and commander-in-chief of the advance, fought against Jin and moved to the south of the Yangtze River.

In the third year of Tai 'an (304), Chen Min was named Guangling, claiming to be brave and invincible, and gradually became independent from Jiang Dong. In the second year of Yongxing, Sima Yue, king of the East China Sea, used Chen Min as the right general and forward commander in order to defeat his opponent in the war for power and profit between kings. Chen Min saw the decline of the Jin Dynasty, so in December, according to Liyang (now Anhui County), he rose up against Jin, ordered his younger brother and his department to attack Jiangzhou (now Nanchang) south, and his younger brother Chen Bindong attacked counties. Liu Ji, Wang Kuang and Ying Miao, the secretariat of Yangzhou in Jin Dynasty, all abandoned the city and fled. He occupied Jiangdong, claimed to be Fu, and was also the commander-in-chief of Jiangdong military affairs, and appointed more than 40 local strongmen and celebrities as generals and governors. There are also people who have entered Mian from the Yangtze River, said Han Yingzhi. Sima Yu, the king of Hejian who was in charge of state affairs, took Zhang Guang as the satrap and led five thousand troops to Jingzhou to meet him. Ricas, the secretariat of Jingzhou, ordered Tao Kan, the satrap of Jiangxia, and Miaoguang, the satrap of Wuling, to station troops in Xiakou (present-day Wuhan), while the satrap of Nanping asked Lingzhan Water Army for support. Chen was ordered to attack Wuchang (now Ezhou, Hubei Province), and Tao Kan was appointed as the vanguard, guarding and leading the army to resist. Tao Kan converted the transport ship into a warship and defeated Chen in succession. Pithu, Zhang Guang and Miao Guang led troops to meet Qian Duan in Changqi (southwest of Huangpi, Hubei). Pitchu led the nomads from the land, and Tao Kan met him on the shore. Miao Guangling led the water army to hide the boat in the water. After Pitchu led Qian Duan's main force into the ambush circle, the amphibious ambush came out, launched a storm and defeated Qian Duan's army. In February of the first year of Yongjia, due to the chaotic criminal management in Chen Min, Gu Rong, Zhou Wei and other Jiangdong clansmen sent envoys to invite General Kim Jong-dong Liu Zhun to send troops to attack Chen Min, and he was willing to be the inside man. Liu Zhun sent Yangzhou secretariat Liu Ji and others to attack Liyang. Chen Min sent his younger brother Chen Chang with tens of thousands of soldiers into Wujiang River (now northeast Anhui County) to stop the attack. Chen Chang and Sima Qianguang are from the same county of Zhou. The messenger killed General Chang. So he persuaded Gan Zhuo to surrender, and Gan Zhuo rebelled. Chen Min led more than 10,000 people to beg for Gan Zhuo, and his army was defeated without fighting. Chen Min fled to the north alone, was captured in Jiangcheng (now northwest of Jurong, Jiangsu), and was beheaded in Jianye (now Nanjing).