Click chemistry, also translated as link chemistry, dynamic combinatorial chemistry and speed matching combinatorial chemistry, is a synthetic concept introduced by chemist Barry Sharples in 200 1. Its main purpose is to complete the chemical synthesis of various molecules quickly and reliably by splicing small units.

In particular, it emphasizes the development of new combinatorial chemical methods based on the synthesis of carbon-heteroatom bonds, and obtains molecular diversity simply and effectively by means of these reactions. The representative reaction of click chemistry is copper-catalyzed azido alkyl Husigen cycloaddition reaction. The concept of click chemistry has made great contributions to the field of chemical synthesis, and it has become one of the most useful and attractive synthesis concepts in many fields such as drug development and biomedical materials.

Introduction to Sharpless:

Barry Sharpless was born in Pennsylvania, USA. Graduated from Stanford University, American chemist, [1] former professor of chemistry at Massachusetts Institute of Technology, Professor W.M.Keck of Scripps Institute in the United States, and foreign academician of China Academy of Sciences. He is the second person to win the Nobel Prize in chemistry twice.

1968 received his Ph.D. degree from Stanford University, initiated research on catalytic asymmetric oxidation reaction, and developed chiral catalysts for oxidation reaction. 2019165438+1October 22nd was elected as a foreign academician of China Academy of Sciences. 200 1 won the 200 1 nobel prize in chemistry for his contribution to chiral catalytic oxidation.

10 On June 5th, 2022, Barry Sharples won the 2022 Nobel Prize in Chemistry together with Danish chemist Morton Meldahl and American chemist Caroline Bertossi for his contribution to the study of click chemistry and bioorthogonal chemistry.