This ototoxic drug is especially harmful to children. Symptoms such as tinnitus will appear when the ears of adults are poisoned in the early stage. After stopping the drug immediately, the poisoning symptoms can be corrected. But babies can't express it.
In addition, pregnant women are also the most vulnerable group. If ototoxic antibiotics are used, the drug will enter the inner ear of the fetus through the placenta, causing damage to the auditory nerve, leading to congenital drug-induced deafness in children.
Moreover, the toxicity of drugs to ears is not immediately manifested, and there are individual differences. Some people have tinnitus and other problems after a few days, and some people have symptoms after a few months. Clinically, deafness usually appears at 1 ~ 2 weeks after medication, and gradually increases, and gradually stabilizes after half a year. It seems that if tinnitus occurs after taking the medicine, you should stop taking the medicine immediately.
Drug abuse is widespread.
As early as 1999, the Ministry of Health promulgated the clinical use standards of commonly used ototoxic drugs, including 30 kinds of drugs such as streptomycin, gentamicin, kanamycin, neomycin, aspirin and erythromycin. According to the regulations, pregnant women and infants under 6 years old are strictly prohibited from using ototoxic antibiotics.
However, there are no laws and regulations prohibiting and restricting the use of ototoxic drugs in China. Liu Peng said that the abuse of these drugs is still widespread. For example, if it is not used by otolaryngologists or opened by small clinics, it is easy to cause abuse. This requires everyone to find out these drugs and find other drugs to replace them when they encounter diseases.
Types of commonly used ototoxic drugs:
1. aminoglycoside antibiotics: streptomycin, gentamicin, kanamycin, micronomicin, neomycin, tobramycin, lincomycin, etc.
2. Non-aminoglycoside antibiotics: chloramphenicol, violomycin, erythromycin, vancomycin, capreomycin, kasugamycin, lidomycin, pachymycin, nitamycin, polymyxin B, etc.
3. Salicylates: aspirin, phenacetin, APC, phenylbutazone, etc.
4. Diuretics: furosemide, uric acid, mercury chloride, etc.
5. Antitumor drugs: cisplatin, nitrogen mustard, bleomycin, aminopurine, etc.
6. Traditional Chinese medicine: aconitine and heavy metal salts (mercury, lead, arsenic, etc. ).
7. Others: quinine, chloroquine, propranolol, bendazine, insulin, iodine, chlorhexidine, etc.