Section 1 Overview
First, the concept and chemical structure of polypeptide
Second, the naming and physicochemical properties of peptides
Section II Classification and Source of Polypeptides
I. Classification of polypeptides
Second, the source of polypeptide
Section 3 Introduction of Polypeptide Application
First, the history of polypeptide research and application
Second, the application of polypeptide in medical field
Third, the application of peptides in food and cosmetics industry
Fourthly, the application of peptides in agriculture and animal husbandry.
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The second chapter is the research and development trend of polypeptide drugs.
Section 1 Discovery of Polypeptide Drugs
First, natural active peptides were found.
The second is the research and development of peptide drugs based on peptide library.
Thirdly, research and development of polypeptide drugs based on protein functional regions.
Fourthly, research and development of polypeptide drugs based on molecular design and modification.
Section II Current Situation and Trend of Peptide Drug Research and Development
First, the development status and trend of polypeptide drug products
Second, the development status and trend of polypeptide drug market
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Chapter III Synthesis and Pharmaceutical Research of Polypeptide Drugs
Section 1 Solid-phase Synthesis of Polypeptide Drugs
Basic principle and process of solid-state synthesis of 1. polypeptide.
Second, the solid-phase synthetic resin of polypeptide
Thirdly, the choice of amino acid protecting groups.
4. Coupling agents commonly used in solid phase synthesis of peptides
V solvation and solvents
Intransitive verbs to protect
Section 2 Liquid Phase Synthesis of Peptide Pharmaceutical Raw Materials
First, step-by-step synthesis
Second, subsection synthesis.
Section III Structural Confirmation of Synthetic Peptides
First, the structure analysis method of polypeptide
Second, the primary structure confirmation of polypeptide
The fourth quarter: Quality study of raw materials of polypeptide drugs
First, the purity test of synthetic peptide.
Secondly, the measurement of the uniformity of physical and chemical properties in synthetic peptides.
Three. Determination of related substances in synthetic peptides
Fourth, disulfide bond analysis of synthetic peptide.
Five, synthetic peptide diastereomer impurity inspection.
6. Detection of artificial modification of synthetic peptides.
Seven, the determination of biological potency of synthetic peptide.
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Chapter IV Study on Peptide Pharmaceutical Preparations
Section 1 Study on Prescription and Technology of Polypeptide Pharmaceutical Preparations
First, the pre-prescription study of polypeptide pharmaceutical preparations
Secondly, the prescription and technology of polypeptide pharmaceutical preparations were studied.
Section II Analysis Methods and Stability Study of Polypeptide Pharmaceutical Preparations
First, the analysis method of polypeptide pharmaceutical preparations
Secondly, the stability of polypeptide pharmaceutical preparations was studied.
Section III Research Progress of Polypeptide Drug Injection Preparations
I. Sustained-release microspheres
Second, implantation
Thirdly, in-situ microspheres
4. liposomes
Verb (abbreviation for verb) microemulsion
Six, in situ hydrogel
Seven. nano particle
Section IV Research progress of non-injection preparations of polypeptide drugs
I. Oral preparation 0
Second, nasal administration.
Third, pulmonary administration.
Fourthly, transdermal drug delivery.
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Chapter V Preclinical Research and Evaluation of Polypeptide Drugs
Study on Pharmacokinetics of Polypeptide Drugs
First, the analysis method of polypeptide drugs in biological samples
2. Pharmacokinetics of polypeptide drugs.
Section 2 Safety Research and Evaluation of Polypeptide Drugs
I. Overview
Second, the general safety evaluation of polypeptide drugs
3. Pharmacokinetics of polypeptide drugs.
Four. Study on immunogenicity and immunotoxicity of polypeptide drugs
Non-clinical safety evaluation case of verb (abbreviation of verb) polypeptide drug
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Chapter VI Polypeptide Drugs Entering Clinical Trials at Home and Abroad
Section 1 Polypeptide Drugs Entering Clinical Trials Abroad
Section 2 Polypeptide drugs have been designated as "single and diluted drugs" by the US FDA over the years.
Section III Polypeptide Drugs Entering Clinical Trials in China
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Chapter VII Polypeptide Drugs Listed at Home and Abroad
Section 1 Polypeptide Drugs Listed Abroad and Their Domestic Registration Information
Section II Polypeptide Drugs Only Listed in China
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appendix
I: Main monographs and periodicals of polypeptide/polypeptide drugs at home and abroad.
Ⅱ: Government Guiding Principles for Drug Development of Synthetic Peptides
Ⅲ: Amino acids commonly used in polypeptide synthesis and their physicochemical parameters.
Ⅳ: Single and Compound Amino Acid Drugs on the Market
V: amino acids protected by Boc and Fmoc commonly used in polypeptide synthesis and their physical and chemical parameters.
ⅵ: Protective groups commonly used in polypeptide synthesis and their physical and chemical parameters
ⅶ: Common resins for solid phase synthesis of peptides and their common parameters.
ⅷ: Condensing agents commonly used in solid phase synthesis of peptides and their physical and chemical parameters.
ⅸ: Common solvents for polypeptide synthesis and their composition ratio.
X: commonly used abbreviations for polypeptide synthesis and polypeptide drugs, with Chinese and English contrast.