Clinically, we sometimes see patients with severe mycobacterial infection, often accompanied by persistent high fever, systemic lymphadenopathy and unbearable bone pain. This serious infection usually occurs in patients with immunodeficiency, but it is sometimes observed in patients who do not seem to have immunodeficiency. Recently, "anti-interferin γ autoantibodies" have been found in these patients. The most obvious symptom is the sudden failure of the immune system, which leads to serious infection. There may be thousands of people who have not been diagnosed with anti-interferon gamma autoantibody disease, which was newly discovered in 2005. In the past, only 10 cases were found, which was considered as a very rare and rare disease. But since 20 12, a large number of patients have been found in Thailand and Southeast Asia. At present, among more than 200 cases in the world, Chang Gung Team has cooperated with major hospitals in Taiwan Province Province to help diagnose more than 70 cases in Taiwan Province Province. However, the medical community's understanding of this disease has just begun, and there may still be thousands of patients in Southeast Asia, including Taiwan Province Province. Patients with poor infection effect treated with antibiotics attack the immune system with γ interferon through autoantibodies, which makes the immune system ineffective and causes serious infection of bacteria or molds such as mycobacteria. At present, clinical treatment can't eradicate autoantibodies, and antibiotics can only be used to inhibit bacterial infection, but the effect is very poor. Many patients are miserable, and some even have amputations. However, the pathogenesis of this disease is completely unknown in academic circles. There are special immune genes that cause serious infections. In the past, it was found that most patients shared a common immune genotype in Taiwan Province Province and Southeast Asia. On this basis, Gu He, an assistant professor at Chang Gung University, and the research team from the Department of Infectious Diseases of Chang Gung Memorial Hospital further found that because the specific fragment of human interferon-γ is similar to Noc2 protein on mold, people with this special immune gene will trigger the body to produce anti-mold antibodies when they are exposed to mold, and then this antibody will gradually evolve into anti-interference antibody, which will lead to the loss of interferon-γ function in patients, affect the immunity of T cells and natural killer cells, and lead to serious infection. This paper, published in Nature Medicine, is the first time that a local team has explained the reasons for the formation of autoimmune antibodies against interferon γ. More importantly, the research was completely completed by a local team, including Dr. Gu from the Institute of Clinical Medicine of Chang Gung University, Dr. Ye from the doctoral class of the Institute of Biomedical Sciences, Dr. Qi Zhiyu from the Department of Infectious Diseases of the Affiliated Hospital of China Medical University. Subscribe to the health Aloha audio-visual channel, read health knowledge more easily, and pay attention to your health every day! Line @ ID: @:/Supply/Article/28680/Unique Autoantibody Diseases Found in Taiwan Province Province of the World Key words: anti-gamma interferon, autoantibodies, immune system, Chang Geng, Mycobacterium, Gu.