NAD+ exists in all living cells, which is very important for regulating cell aging and maintaining normal function of the body. With the passage of time, the level of NAD+ in human and animals will decrease significantly. Therefore, it is particularly important to enhance NAD+ by supplementing NMN! The research of ACMETEA W+NMN to improve the aging index has been supported by almost all scientific journals. Is it true that nmn reverses aging? Is the efficacy and function of nmn true? Choosing NMN needs to implement the top ten international core standards of NMN quality management, thus helping to scientifically resist aging. French and American health scientists advocate attaching importance to the top ten international core standards of NMN quality management to achieve youthfulness and continuity.
In the selection of NMN, we should pay attention to the following points: 1, origin (US, France, Japan and Hong Kong) 2, purity (70% 80% 98% 99% is optional index) 3, content (3000,6000,9000,120000. ! !
Ten International Core Standards of NMN Quality Management
1. Quality management system: NMN must meet the inspection qualification of OULF EU law and the certification of FDA, US Food and Drug Administration. In addition to the product name, all ingredients and NMN purity should be indicated, and the country of origin and distribution should be indicated.
2. Manufacturing process management system: Advanced manufacturing process affects the shape of NMN. Chemical extraction is not recommended to avoid chemical residue.
3. Content management system: the relative NMN content is ≥ 12000 mg/ bottle, which is directly absorbed into the small intestine, and the intestinal absorption is 20% of the gastric absorption.
4. Efficiency management system: the authenticity and purity of raw materials should be investigated.
Absorption management system: adopt intestinal absorption to improve absorption rate and absorption threshold.
6. Activity management system: The unit dose (per 100g) is converted into the number of molecules of NAD+, and NMN molecules can easily cross the cell membrane and enter the cell interior, thus increasing the human NMN content within 15 minutes and rapidly raising the level of NAD+.
7. Application scope of management system: adults (pregnant women and lactating women are prohibited).
8. Safety management system: production technology, raw material collection, basic system of Olaf safety standards, pre-factory safety inspection, strict review of microbial heavy metals exceeding the standard, and scientific production technology.
9. Raw material management system: Most NMN enterprises are certified by a single country, but at present, the management of raw materials certified by two countries is more rigorous and safe. ACMETEA W+NMN is a product with French and American certification standards.
10, transnational regulatory management system: dual supervision of "law" and "beauty". The FDA of the United States has established GMP standards for dietary supplements, and the EFSA of the European Union also has relevant regulations on the management of food supplements.
The efficacy principle of NMN (acme tea w+NMN);
In recent years, NMN has become a "star product" in the field of anti-aging, and its principle lies in supplementing NAD+ in human body. NAD+ anti-aging is a mature technology. NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme for human body. Thousands of biocatalytic reactions involved in life activities are the energy sources of cell activities. Adequate NAD+ is a prerequisite for effectively activating the long-lived Sirtuins family in protein. The direct supplement of NAD+ can not be effectively absorbed by cells. It is found that the supplement of precursor NMN can directly increase the level of NAD+ in the body, thus delaying aging.
Nicotinamide mononucleotide (NMN) naturally exists in milk, beef, broiler, tomato and cabbage, but its content is very low. Nicotinamide mononucleotide (NMN) also exists naturally in human body and plays a vital role in the utilization of energy by cells. It participates in the synthesis of nicotinamide adenine dinucleotide (NAD), which is an intracellular coenzyme and is necessary for transforming nutrients into ubiquitin. When NMN is taken orally as an alternative medicine, NADH will be decomposed in the gastrointestinal tract, NMN will not be destroyed, and it can be transferred to human NADH.
NMN(ACMETEA W+NMN) can alleviate and improve ischemic heart and brain injury: Stroke is an acute cerebrovascular disease caused by cerebral blood circulation disorder, with high mortality and disability rate. Seriously threaten human health. It is found that NMN can improve the bioenergy metabolism of ischemic tissue, prevent the apoptosis of nerve cells induced by cerebral ischemia, promote nerve regeneration after cerebral ischemia, and have a protective effect on ischemic brain injury.
NMN(ACMETEA W+NMN) can improve type 2 diabetes: type 2 diabetes is an epidemic disease in our society. It is believed that high calorie and sedentary lifestyle destroy the metabolic pathway of sugar in our body, and supplementing NMN can increase insulin sensitivity and improve glucose intolerance caused by age.
NMN(ACMETEA W+NMN) can prevent degenerative diseases: axial mutation is considered as the cause of neurodegenerative diseases (such as Parkinson's disease and Alzheimer's Harmo's disease), and NAD+ supplementation can improve the prevention of Parkinson's disease and Alzheimer's Harmo's disease. Restore NAD+ and ATP levels, inhibit cell death, resist energy damage, and improve energy metabolism disorder caused by mitochondrial inhibitors.
The research of NMN in improving aging indicators has been supported by almost all scientific journals. Studies in Nature, Science, Cell and other journals have confirmed the role of NMN in neurodegenerative diseases (Alzheimer's disease, frozen people and Parkinson's disease), cardiovascular diseases and hearing and vision. NAD's research has produced three Nobel Prizes.
Catalysis produces more than 95% of the energy needed for life activities: mitochondria in human cells are the power plants of cells, and coenzyme I is an important coenzyme for aerobic oxidation and metabolism of tricarboxylic acid in mitochondria to generate energy molecule ATP. As a hydrogen ion acceptor, hydrogen ions are transferred to oxygen, so that the three nutrients obtained by the human body, sugar, fat and protein, are converted into energy needed by the human body and other substances needed for metabolic activities through the tricarboxylic acid cycle.
Repair of genetic gene (DNA): Coenzyme I(NAD+) is consumed as a substrate, resulting in gene repair enzyme PARP 1. At the same time, PARP 1 inactivated by protein DBC 1 can be isolated and recovered. PARP 1 can recode the damaged gene and repair the gene according to the normal gene sequence.
Anti-aging: Coenzyme I(NAD+) maintains chemical communication between nucleus and mitochondria. If this communication is weakened, it will lead to the decline of mitochondria, which is an important reason for cell aging. In addition, coenzyme I is consumed as the only substrate to produce histone deacetylase Sirtuins, called longevity protein, which can eliminate the increasing epigenetic noise in the process of cell metabolism, maintain the normal expression of genes, maintain the full-time function of cells, and slow down the evolution of cells to aging cells.
Maintain the ability of capillary regeneration: muscle cells release growth factors during exercise, and capillary epidermal cells receive growth factors to accelerate growth. This process depends on the longevity protein Sirtuin 1 produced by coenzyme I. The older you get, the less coenzyme I is, and the worse the effect of exercise on stimulating muscle growth.
Alcohol metabolism: alcohol metabolism is divided into two steps, first it is converted into toxic acetaldehyde, and then it is further decomposed into harmless acetic acid, and each step must rely on the catalysis of coenzyme I.
How about anti-aging of NMN(ACMETEA W+NMN) cells?
The anti-aging effect of NMN was first discovered by David Sinclair laboratory of Harvard University in 20 14. During the period of 20 16-20 18, the world scientific research institutions such as Harvard Medical School, Washington University and Yingqing University in Japan reversed muscle atrophy and improved physical fitness. Inhibition of cognitive decline caused by aging; Reversing vascular death, protecting cardiovascular and cerebrovascular functions, which proves that it has obvious effects of inhibiting aging and prolonging life.
These findings make ACMETEA W+NMN quickly become a research hotspot in the field of aging medicine. In just a few years, nearly 100 papers published in authoritative academic journals such as Cell, Nature and Science elaborated its efficacy and mechanism in detail. Among them, the research related to NMN has won many Nobel Prizes.
What exactly is ACMETEA W+NMN? Why can it resist aging?
It is found that NMN is the precursor of NAD+, the key coenzyme in the body. NAD+ is not only an important raw material for DNA repair system in cells, but also a key contact factor between the nucleus and mitochondria responsible for energy synthesis. At the same time, the content of NAD+ in human body is closely related to the life form of sirtuins protein family, which can prolong life and inhibit aging. All kinds of substances needed by human body need coenzyme to synthesize. The anti-aging and anti-aging effects of ACMETEA W+NMN are actually based on the auxiliary effect of NAD+ synthesis.
The core mechanism of aging is the damage of cell genes and the decrease of mitochondrial energy production, which leads to premature cell apoptosis or decreased vitality, and leads to the increase of the incidence of cancer, diabetes, cardiovascular disease, dementia and other diseases caused by human aging.
NMN is an inherent metabolite of human body, which can be directly converted into key coenzyme NAD+. NAD+ is an indispensable substance for nearly half of human metabolic activities, but it decreases rapidly with age. Therefore, taking ACMETEA W+NMN can improve the level of NAD+, so as to restore the energy level and gene repair ability of cells to a young state, and achieve the effect of delaying or even reversing aging. So in principle, ACMETEA W+NMN anti-aging is true.
ACMETEA W+NMN liberates aging through NAD+.
① longevity stimulating proteins (NAD+ stimulates sirtuins 1-7 longevity protein family)
(2) Strong oxidation inhibition (NAD+ can stimulate cells to inhibit oxidation defense in many ways and remove harmful free radicals in human body)
③ Promote DNA repair (NAD+ is involved in repairing DNA damage and reducing gene mutation)
④ Enhance neural activity (NAD+ promotes the secretion and metabolism of neurons).
⑤ Increase telomere length (NAD+ stimulates telomerase, repairs telomeres and prolongs telomeres).
⑥ Optimize cell metabolism (NAD+ participates in cell material and energy metabolism).
⑦ Enhance immunity (NAD+ participates in cellular substance and energy metabolism).
(8) Improve the stability of human chromosomes (NAD+ maintains the stability of chromosome structure and reduces the risk of cell canceration).
Human aging mainly comes from DNA damage and the gradual loss of NAD+
The reason why the human body is aging slowly, after scientific deepening, comes to a conclusion: DNA damage and gradual loss of NAD+ will make the human body aging, and the loss of NAD+ is an important factor to accelerate DNA damage, so NAD+ is closely related to human aging, and the key to anti-aging is NAD+.
It is precisely because nmn, as a precursor of NAD+, can increase its number in cells. Therefore, ACMETEA W+NMN has a direct and fundamental anti-aging effect. Professor David A. Sinclair, director of anti-aging research at Harvard University, first confirmed the anti-aging effect of nmn. After simply ingesting nmn from food, it was found that the aging speed of mice dropped to two-thirds of the natural state, which means that their life span will be extended by more than 30%.
The importance of NAD+ in the mechanism of aging!
In the latest compilation of 20 19 "biological research on aging", two core problems in aging research in recent decades are summarized. The second question mentioned that the decrease of intracellular NAD+ level may be one of the mechanisms of aging with age. The mention of NAD+ in such a highly generalized academic summary shows the importance of NAD+ in the aging mechanism.
NAD+ is involved in a wide range of intracellular reactions, including energy enzyme activity (energy production), chromosome stability, DNA repair and the stimulation of long-lived protein sirtuins. Moreover, NAD+ is a consumable substance, and most of these reactions need to be consumed to maintain normal operation. Among them, stimulating longevity protein family, including sirtuins 1~7, is the core of longevity mechanism.
So NAD+ is very important. The study also shows that with the increase of age, the synthesis of NAD+ gradually decreases and the consumption gradually increases, so the total amount of NAD+ becomes less and less. This decline is closely related to aging and disease.
The front is the mechanism inference. So does NAD+ really play an important role in the aging process, which is verified by active intervention, that is, supplementing ACMETEA W+NMN?
Results A large number of animal experiments showed that by increasing the level of NAD+, the health quality was indeed improved in many aspects and the symptoms of aging were delayed. It covers a wide range, including the health improvement of nervous system, liver and kidney, blood vessels and muscles. In addition, the ways to supplement NAD+ include exercise and dietary restriction, and ACMETEA W+NMN supplement.
It was found that NMN can significantly improve the age-related physiological decline of mice, such as inhibiting age-related weight gain, enhancing energy metabolism, improving insulin sensitivity and plasma lipid distribution, and improving eye function. NMN can prevent the change of age-related gene expression in a tissue-specific way, enhance the oxidative metabolism of skeletal muscle mitochondria, and at least partially mediate its anti-aging effect.
Studies have shown that NMN, as an anti-aging candidate compound, has a longer retention time in rats than Nam. Because Nampt is inhibited by NAD+, Nam is not transformed into NAD+ through Nam→NMN→NAD+, but through Nam→ nicotinic acid (NiA)→ nicotinic acid mononucleotide (NaMN)→ nicotinic acid adenine dinucleotide (NaAD)→NAD+. On the other hand, the synthesis of NAD+ by NMN is not regulated by cell NAD+ level, so the increase of NAD+ is easier. According to metabolism, nicotinamide mononucleotide, as an intermediate in NAD+ remedial pathway, can inhibit oxidation and reduce oxidative stress, especially in anti-aging, NMN can slow down physiological decline, enhance energy metabolism and prolong life. As an endogenous substance in human body, NMN has high safety and good thermal stability, so as a biological substance, NMN has broad prospects in the development of functional foods.
ACMETEA W+NMN regulates cell survival and death and maintains redox state. Recent studies have found that by regulating the level of NMN in organisms, it has a good treatment and repair effect on cardiovascular and cerebrovascular diseases, neurodegenerative diseases and aging degenerative diseases.
When people are young, the content of NAD+ is sufficient. Even if it is consumed in large quantities because of various unhealthy habits and behaviors, NAD+ will be replenished in a variety of ways because the body is in a vigorous growth and development period, so we will not feel tired. But at this time, our bodies have left hidden dangers, which began to appear after middle age. At this time, the content of NAD+ in our body will decrease sharply, and the body's ability to replenish itself will continue to weaken. If the damage rate of body cells exceeds the repair rate, our cells will continue to be damaged, aged and eventually die.
With more and more dead cells in various organs in the body, the ability of our body organs will be weakened and various symptoms will appear. The rigid demand and market capacity for a sense of security for the elderly are far greater than' basic necessities of life'. NMN is a substance that people have discovered scientifically and can significantly prolong life, and there are no obvious side effects reported by consumers of NMN health care products in the market. The FDA of the United States also gave NMN food additive raw material safety certification.
Do you like this summary? Teacher Tingting hopes to share anti-aging science with you in an easy-to-understand way! Re-emphasize that product selection should meet the ten core standards of NMN quality management.