Modern medical research shows that emotional changes can directly affect various physiological activities in the human body. Excessive sadness and persistent intense mental trauma, such as bad emotional state such as widowhood, divorce, career failure and fear, will bring adverse consequences to people's health. When the body is in a state of high mental tension or stress, it can produce a series of changes in physiology, neuroendocrine, neurobiochemistry, immune function, psychological behavior and so on. According to statistics, 74% of gastrointestinal diseases are caused by bad mood.
The study found that:
First, emotions can change the secretion of gastric juice, such as anger, tension, panic, hatred, anxiety, etc., which can reduce the secretion and acidity of gastric juice and weaken gastric motility; The changes of depression, frustration, frustration and disappointment increase the secretion and acidity of gastric juice and enhance gastric motility. Stress, such as fire, flood, earthquake and serious diseases, can cause gastric mucosal arteriovenous short circuit (especially in the fundus and body), lead to mucosal ischemia and necrosis, weaken mucosal defense function, and lead to stress ulcer.
2. Stimulus factors such as widowhood, divorce, fear and failure are related to the occurrence of peptic ulcer. The reasons are as follows: long-term mental stress, emotional excitement and other factors make the autonomic nerve function disorder. One is to stimulate parietal cells and G cells excessively through hypothalamus-vagus nerve nucleus-vagus nerve, so as to increase gastric acid secretion; Secondly, by exciting the sympathetic nervous system, the mucosal blood vessels contract, ischemic necrosis, and the mucosal defense function is weakened; In addition, by exciting the hypothalamus-pituitary-adrenal axis, the secretion of adrenocortical hormone is increased, which can stimulate the secretion of gastric acid and pepsinogen and inhibit the secretion of gastric mucus, thus forming peptic ulcer.
3. Anger, tension, panic, hatred and anxiety can also cause continuous contraction of colon, narrowing of intestinal cavity, enhanced secretion of lysozyme, fragile mucosa and punctate bleeding; However, depression, frustration and disappointment reduce intestinal peristalsis and secretion. The reason is also that nerve factors increase the excitability of vagus nerve, stimulate intestinal peristalsis, enhance the secretion function of intestinal mucosa, weaken the protective mucosal barrier of colon, and cause mucosal injury. At the same time, the blood vessels of mucosa and submucosa change, causing bleeding and eventually leading to ulcerative colitis.
Fourthly, the pathogenesis of functional dyspepsia is complex and has not been fully understood so far. Emotional changes are closely related to its occurrence, development and prognosis. Patients with functional dyspepsia are often accompanied by emotional disorders such as anxiety and depression, while somatization symptoms, sensitivity, depression and anxiety are significantly higher than those of normal people. The reason is that emotional changes lead to decreased gastric tension, gastric motility disorder and increased sensitivity.
5. Gastroesophageal reflux disease is also a disorder of gastric and esophageal motility caused by emotional changes, which makes the sphincter of the lower esophagus relax, the resting pressure decreases, the sensitivity of the esophagus to gastric acid increases, and the esophageal clearance ability decreases.
Six, the occurrence and aggravation of irritable bowel syndrome is related to emotional changes. Anxiety, depression, excitement and fear stimulate the body, causing the dysfunction of the intestinal "nerve-immune-endocrine" network, which eventually leads to abnormal intestinal dynamics and visceral sensation. In short, bad emotions can lead to hypothalamic dysfunction through the cerebral cortex. Hypothalamus is a subcortical center related to emotion, which can affect gastrointestinal function through autonomic nervous system, thus leading to gastrointestinal dysfunction.
From this point of view, how to maintain a good mood has become a problem that cannot be ignored in people's lives. In this regard, we put forward the following suggestions: ① strengthen ideological cultivation, replace feelings with reason, and hold a correct attitude towards life and society; (2) Eliminate the troubles of unpleasant things as soon as possible; ③ Be broad-minded, tolerant and kind, improve interpersonal relationships and create a relaxed and harmonious environment; 4 control your emotions, avoid ecstasy and rage, and be good at controlling your feelings with reason; ⑤ Actively participate in appropriate social activities, adjust emotions and enhance friendship.
Of course, once gastrointestinal symptoms appear, we should first consult an experienced specialist and eliminate organic diseases through advanced instruments, so as to ensure that the condition will not be delayed. At the same time, some antipsychotic drugs, such as anti-anxiety drugs and antidepressants, can be used appropriately. Diazepam, perphenazine, imipramine, nitrodiazepam and doxepin are commonly used in clinic, but these drugs have different degrees of side effects. In recent years, some compound preparations have come out, with few adverse reactions and remarkable effects. For example, we often use droperiseton melitracen tablets, 1-2 tablets once a day, and the effect is good.
The reason why the intestines and stomach refuse to serve us well is related to our disrespect for them. As long as you eat according to the biological clock of the gastrointestinal tract, develop good eating habits and maintain a peaceful attitude, the gastrointestinal tract will not be "much ado about nothing."
Li Fangxia, director and chief physician of Department of Gastroenterology, Yuncheng Central Hospital, chairman of Yuncheng Gastroenterology Professional Committee, vice chairman of Yuncheng Hepatology Professional Committee, member of Shanxi Gastroenterology Professional Committee, and vice president of Shanxi Medical Association Gastroenterology Branch. He has been engaged in clinical work for 30 years, and has made in-depth exploration on intractable diseases of digestive system, various chronic liver diseases and psychosomatic diseases of gastrointestinal tract. With high attainments, rich clinical experience, dedication, dedication and care for patients, he has been awarded the title of "March 8th Red Flag Bearer" for many times, a model of professional ethics in Yuncheng, and an advanced individual in Yuncheng's health system. He won the personal second-class merit of 20656. 1 0000000065 in two civilization construction activities in Yuncheng, and wrote more than 30 academic papers, which won the title of Yuncheng Science and Technology.