Professor Du Lixin has been engaged in the research and teaching of animal genetic resources protection, genetic breeding and biotechnology for many years. He has successively presided over more than ten major scientific and technological key projects such as the National Natural Science Foundation, the "863" Program and supporting programs, won six national and provincial scientific and technological progress awards, published more than 50 papers/kloc-0 in domestic and foreign journals and international academic conferences, edited 5 books, and trained more than 50 doctoral and master students. Perfecting the theory of systematic preservation of livestock and poultry genetic resources, and constructing the most suitable model for the preservation of pig, cattle, sheep and poultry genetic resources in the emerging stage of China; The main genes and their genetic rules of multiple births in small-tailed Han sheep and Tan sheep, as well as the evolutionary path of China sheep, were discovered and determined. A rapid method for detecting stress-sensitive genes in pigs can simultaneously detect three molecular markers, namely, estrogen receptor gene, follicle-stimulating hormone β subunit gene and obesity gene controlling body fat deposition by one PCR reaction. Twenty sheep genes, such as BMPR-IB, BMP 15, GDF9, Y-box, TLRs and porcine growth differentiation factor 1 1mRNA, were cloned, sequenced and analyzed for allelic variation. More than 20 genes affecting cow mastitis were identified, and related molecular diagnosis methods were established. The EST-SSR molecular marker technology system of cattle and sheep was developed. Germline chimeric chicken, chicken embryonic stem cell line, transgenic chicken and somatic cell nuclear transfer rabbit were prepared. At present, according to the development needs and actual resources of animal genetics and breeding in China, we are hosting the "863" and scientific and technological support plan, and carrying out research on sheep variety improvement, resource protection and molecular breeding technology with scientific research institutes and breeding enterprises in Beijing, Shandong, Hebei, Inner Mongolia, Jilin, Xinjiang, Gansu and Ningxia.