1, blank control: refers to the control group selected in clinical trials without any control drugs.
2. Placebo control: refers to the control given a placebo. Placebo is similar to the experimental drug in size, color and shape, but it does not contain any active ingredients. In clinical trials, both sides took placebo and experimental drugs respectively to test the medicinal value of experimental drugs.
3. Experimental control: In clinical trials, the factors of both sides are the same. In the experiment, one factor of one group changes, while the other group remains unchanged. The experimental results of the two groups were compared.
4. Standard control: refers to comparing the known classic drugs with experimental drugs under standard conditions.
Clinical trial design or clinical research scheme is the basis of clinical research design, implementation, reporting and evaluation. A high-level clinical research paper is not only advanced in theory and method, but also has a complete and rigorous experimental design and scientific statistical methods.
The rapid development of evidence-based medicine proves that papers based on standardized and rigorous scientific research design and correct use of statistics are high-quality papers. However, it can be seen from some surveys that the quality of domestic scientific research papers, especially clinical trial papers, is not high, and some so-called randomized clinical trials (RCT) are not real RCT. Studies at home and abroad show that the imperfection of scientific research design is one of the important reasons for the low quality of papers.
Two-thirds of the contributions of this journal are clinical research papers. Through the analysis of contributions in recent years, the author finds that high-quality papers are often standardized in scientific research design and correct in statistical methods, while most of the rejected papers are simple and rough in scientific research design, which leads to obvious scientific research "hard injury".
A considerable part of the final published papers can only be published after repeated revisions. In order to help authors, especially young clinicians, improve their writing level, this paper mainly summarizes and summarizes some commonly used basic norms from the aspects of clinical research design.