At present, the main research fields are radiotherapy and signal transduction of nasopharyngeal carcinoma. After returning to China in 2003, he cooperated with dominant disciplines, clinics and foreign countries to carry out related research work. In cooperation with Dr. MH-Lee, he applied for and obtained five fund grants to explore the role and mechanism of 14-3-3σ and p27 genes in the treatment of cancer and radiation tolerance. The effect and mechanism of adenovirus-mediated 14-3-3σ gene transfection in the treatment of NPC have been discussed, and it has been confirmed that 14-3-3σ negatively regulates Akt and inhibits the proliferation and tumorigenesis of Akt overexpressed cells. China has applied for an invention patent (application number: 2005 1 0102126.0), and published SCI papers1article [mol cancer ther (if: 5.242)] by the first author. At the same time, in cooperation with Professor Huang Wenlin and Professor Xia Yunfei from the State Key Laboratory of Oncology in South China of our university, the first major member participated in the research on new prognostic indicators of nasopharyngeal carcinoma (30570543) sponsored by the National Natural Science Foundation of China (NYD-SP8) sponsored by Professor Xia Yunfei, and participated in the "973 Plan" sponsored by Professor Huang Wenlin and the key breakthrough projects in key areas of Guangdong Province. Mainly engaged in applied basic research of radiotherapy, and participated in publishing SCI papers 1 article [Cell Biology International (IF: 1.05438+09)].
At present, the comparative model of NPC cells with different radiation resistance induced by crawling intermittent high-dose X-rays and genetic background is adopted. It is planned to screen the differences between CNE-2R and its parent CNE-2 by Qualcomm quantity detection, and to explore the relationship between them, so as to obtain information or evidence that miRNA regulates different proteins after transcription, and provide scientific basis for clarifying the mechanism of radiation tolerance of nasopharyngeal carcinoma, mining sensitive indicators for evaluating radiation tolerance, and establishing new targets for reversing radiation tolerance.